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The influencing factors and functions of DNA G‐quadruplexes

G‐quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main strand polarity of the G‐quadruplex. Meanwhile, th...

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Autores principales: Yuan, Wen‐Fang, Wan, Lin‐Yan, Peng, Hu, Zhong, Yuan‐Mei, Cai, Wen‐Li, Zhang, Yan‐Qiong, Ai, Wen‐Bing, Wu, Jiang‐Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383576/
https://www.ncbi.nlm.nih.gov/pubmed/32056246
http://dx.doi.org/10.1002/cbf.3505
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author Yuan, Wen‐Fang
Wan, Lin‐Yan
Peng, Hu
Zhong, Yuan‐Mei
Cai, Wen‐Li
Zhang, Yan‐Qiong
Ai, Wen‐Bing
Wu, Jiang‐Feng
author_facet Yuan, Wen‐Fang
Wan, Lin‐Yan
Peng, Hu
Zhong, Yuan‐Mei
Cai, Wen‐Li
Zhang, Yan‐Qiong
Ai, Wen‐Bing
Wu, Jiang‐Feng
author_sort Yuan, Wen‐Fang
collection PubMed
description G‐quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main strand polarity of the G‐quadruplex. Meanwhile, the different conformations of G‐quadruplexes have certain influences on their biological functions, such as the inhibition of transcription, translation, and DNA replication. In addition, G‐quadruplex binding proteins also affect the structure and function of G‐quadruplexes. Some chemically synthesized G‐quadruplex sequences have been shown to have biological activities. For example, bimolecular G‐quadruplexes of AS1411 act as targets of exogenous drugs that inhibit the proliferation of malignant tumours. G‐quadruplexes are also used as vehicles to deliver nanoparticles. Thus, it is important to identify the factors that influence G‐quadruplex structures and maintain the stability of G‐quadruplexes. Herein, we mainly discuss the factors influencing G‐quadruplexes and the synthetic G‐quadruplex, AS1411. SIGNIFICANCE OF THE STUDY: This review summarizes the factors that influence G‐quadruplexes and the functions of the synthetic G‐quadruplex, AS1411. It also discusses the use of G‐quadruplexes for drug delivery in tumour therapy.
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spelling pubmed-73835762020-07-27 The influencing factors and functions of DNA G‐quadruplexes Yuan, Wen‐Fang Wan, Lin‐Yan Peng, Hu Zhong, Yuan‐Mei Cai, Wen‐Li Zhang, Yan‐Qiong Ai, Wen‐Bing Wu, Jiang‐Feng Cell Biochem Funct Review Articles G‐quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main strand polarity of the G‐quadruplex. Meanwhile, the different conformations of G‐quadruplexes have certain influences on their biological functions, such as the inhibition of transcription, translation, and DNA replication. In addition, G‐quadruplex binding proteins also affect the structure and function of G‐quadruplexes. Some chemically synthesized G‐quadruplex sequences have been shown to have biological activities. For example, bimolecular G‐quadruplexes of AS1411 act as targets of exogenous drugs that inhibit the proliferation of malignant tumours. G‐quadruplexes are also used as vehicles to deliver nanoparticles. Thus, it is important to identify the factors that influence G‐quadruplex structures and maintain the stability of G‐quadruplexes. Herein, we mainly discuss the factors influencing G‐quadruplexes and the synthetic G‐quadruplex, AS1411. SIGNIFICANCE OF THE STUDY: This review summarizes the factors that influence G‐quadruplexes and the functions of the synthetic G‐quadruplex, AS1411. It also discusses the use of G‐quadruplexes for drug delivery in tumour therapy. John Wiley and Sons Inc. 2020-02-13 2020-07 /pmc/articles/PMC7383576/ /pubmed/32056246 http://dx.doi.org/10.1002/cbf.3505 Text en © 2020 The Authors. Cell Biochemistry and Function published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Yuan, Wen‐Fang
Wan, Lin‐Yan
Peng, Hu
Zhong, Yuan‐Mei
Cai, Wen‐Li
Zhang, Yan‐Qiong
Ai, Wen‐Bing
Wu, Jiang‐Feng
The influencing factors and functions of DNA G‐quadruplexes
title The influencing factors and functions of DNA G‐quadruplexes
title_full The influencing factors and functions of DNA G‐quadruplexes
title_fullStr The influencing factors and functions of DNA G‐quadruplexes
title_full_unstemmed The influencing factors and functions of DNA G‐quadruplexes
title_short The influencing factors and functions of DNA G‐quadruplexes
title_sort influencing factors and functions of dna g‐quadruplexes
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383576/
https://www.ncbi.nlm.nih.gov/pubmed/32056246
http://dx.doi.org/10.1002/cbf.3505
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