Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis

Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and structural data for PFK from three human pathogenic trypanosomatids, illustrating intriguing differences that may reflect evolutionary adaptations t...

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Detalles Bibliográficos
Autores principales: Fernandes, Peter M., Kinkead, James, McNae, Iain W., Vásquez‐Valdivieso, Monserrat, Wear, Martin A., Michels, Paul A. M., Walkinshaw, Malcolm D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383607/
https://www.ncbi.nlm.nih.gov/pubmed/31838765
http://dx.doi.org/10.1111/febs.15177

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