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New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event

Atherosclerosis is considered an irreversible process, with crucial contribution of inflammation and immune cells. Impact of cancer immunotherapy on a partly immune-driven disease, such as atherosclerosis, is poorly understood, but preclinical models suggest its worsening on programmed death/ligand-...

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Autores principales: Lamberti, Giuseppe, Gelsomino, Francesco, Brocchi, Stefano, Poerio, Antonio, Melotti, Barbara, Sperandi, Francesca, Gargiulo, Mauro, Borghi, Claudio, Fiorentino, Michelangelo, Ardizzoni, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383634/
https://www.ncbi.nlm.nih.gov/pubmed/32782484
http://dx.doi.org/10.1177/1758835920913801
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author Lamberti, Giuseppe
Gelsomino, Francesco
Brocchi, Stefano
Poerio, Antonio
Melotti, Barbara
Sperandi, Francesca
Gargiulo, Mauro
Borghi, Claudio
Fiorentino, Michelangelo
Ardizzoni, Andrea
author_facet Lamberti, Giuseppe
Gelsomino, Francesco
Brocchi, Stefano
Poerio, Antonio
Melotti, Barbara
Sperandi, Francesca
Gargiulo, Mauro
Borghi, Claudio
Fiorentino, Michelangelo
Ardizzoni, Andrea
author_sort Lamberti, Giuseppe
collection PubMed
description Atherosclerosis is considered an irreversible process, with crucial contribution of inflammation and immune cells. Impact of cancer immunotherapy on a partly immune-driven disease, such as atherosclerosis, is poorly understood, but preclinical models suggest its worsening on programmed death/ligand-1 (PD-1/PD-L1) inhibitors. In a previously reported cohort of 11 patients with non-small cell lung cancer (NSCLC) treated with nivolumab and pre-existing complicated atheromatous plaques, 3 patients had a dramatic radiologic reduction of aortic plaques while on nivolumab; of these 3, 2 died receiving no further treatment. The remaining patient was an 83-year-old woman with history of arterial hypertension and hypothyroidism who was diagnosed with locally advanced squamous NSCLC. At relapse, complicated aortic atheromatous plaques were demonstrated on scans. The patient was then treated with nivolumab obtaining stable disease at radiological assessment, which also demonstrated almost complete vanishing of aortic plaques. After relapse and interval treatment with chemotherapy, she experienced new development of aortic atheromatous plaques. At further relapse she received atezolizumab, which yielded disease response and new reduction in aortic plaques, until nearly complete resolution. The observation of a repeated improvement of atheromatous plaques on treatment with PD-1/PD-L1 inhibitors favors the protective role of T cells on atheromatous plaques that is impaired by PD-L1 expression by plaque-associated macrophages. Validation by independent and prospective observation is needed.
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spelling pubmed-73836342020-08-10 New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event Lamberti, Giuseppe Gelsomino, Francesco Brocchi, Stefano Poerio, Antonio Melotti, Barbara Sperandi, Francesca Gargiulo, Mauro Borghi, Claudio Fiorentino, Michelangelo Ardizzoni, Andrea Ther Adv Med Oncol Case Report Atherosclerosis is considered an irreversible process, with crucial contribution of inflammation and immune cells. Impact of cancer immunotherapy on a partly immune-driven disease, such as atherosclerosis, is poorly understood, but preclinical models suggest its worsening on programmed death/ligand-1 (PD-1/PD-L1) inhibitors. In a previously reported cohort of 11 patients with non-small cell lung cancer (NSCLC) treated with nivolumab and pre-existing complicated atheromatous plaques, 3 patients had a dramatic radiologic reduction of aortic plaques while on nivolumab; of these 3, 2 died receiving no further treatment. The remaining patient was an 83-year-old woman with history of arterial hypertension and hypothyroidism who was diagnosed with locally advanced squamous NSCLC. At relapse, complicated aortic atheromatous plaques were demonstrated on scans. The patient was then treated with nivolumab obtaining stable disease at radiological assessment, which also demonstrated almost complete vanishing of aortic plaques. After relapse and interval treatment with chemotherapy, she experienced new development of aortic atheromatous plaques. At further relapse she received atezolizumab, which yielded disease response and new reduction in aortic plaques, until nearly complete resolution. The observation of a repeated improvement of atheromatous plaques on treatment with PD-1/PD-L1 inhibitors favors the protective role of T cells on atheromatous plaques that is impaired by PD-L1 expression by plaque-associated macrophages. Validation by independent and prospective observation is needed. SAGE Publications 2020-07-24 /pmc/articles/PMC7383634/ /pubmed/32782484 http://dx.doi.org/10.1177/1758835920913801 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Lamberti, Giuseppe
Gelsomino, Francesco
Brocchi, Stefano
Poerio, Antonio
Melotti, Barbara
Sperandi, Francesca
Gargiulo, Mauro
Borghi, Claudio
Fiorentino, Michelangelo
Ardizzoni, Andrea
New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title_full New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title_fullStr New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title_full_unstemmed New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title_short New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
title_sort new disappearance of complicated atheromatous plaques on rechallenge with pd-1/pd-l1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383634/
https://www.ncbi.nlm.nih.gov/pubmed/32782484
http://dx.doi.org/10.1177/1758835920913801
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