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Subsistence and complexity of antimicrobial resistance on a community‐wide level

There are a multitude of resistance strategies that microbes can apply to avoid inhibition by antimicrobials. One of these strategies is the enzymatic modification of the antibiotic, in a process generally termed inactivation. Furthermore, some microorganisms may not be limited to the mere inactivat...

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Autores principales: Perri, Riccardo, Kolvenbach, Boris A., Corvini, Philippe F. X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383678/
https://www.ncbi.nlm.nih.gov/pubmed/32286010
http://dx.doi.org/10.1111/1462-2920.15018
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author Perri, Riccardo
Kolvenbach, Boris A.
Corvini, Philippe F. X.
author_facet Perri, Riccardo
Kolvenbach, Boris A.
Corvini, Philippe F. X.
author_sort Perri, Riccardo
collection PubMed
description There are a multitude of resistance strategies that microbes can apply to avoid inhibition by antimicrobials. One of these strategies is the enzymatic modification of the antibiotic, in a process generally termed inactivation. Furthermore, some microorganisms may not be limited to the mere inactivation of the antimicrobial compounds. They can continue by further enzymatic degradation of the compounds' carbon backbone, taking nutritional and energetic advantage of the former antibiotic. This driving force to harness an additional food source in a complex environment adds another level of complexity to the reasonably well‐understood process of antibiotic resistance proliferation on a single cell level: It brings bioprotection into play at the level of microbial community. Despite the possible implications of a resistant community in a host and a lurking antibiotic failure, knowledge of degradation pathways of antibiotics and their connections is scarce. Currently, it is limited to only a few families of antibiotics (e.g. β‐lactams and sulfonamides). In this article, we discuss the fluctuating nature of the relationship between antibiotic resistance and the biodegradation of antibiotics. This distinction mainly depends on the genetic background of the microbe, as general resistance genes can be recruited to function in a biodegradation pathway.
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spelling pubmed-73836782020-07-27 Subsistence and complexity of antimicrobial resistance on a community‐wide level Perri, Riccardo Kolvenbach, Boris A. Corvini, Philippe F. X. Environ Microbiol Opinion There are a multitude of resistance strategies that microbes can apply to avoid inhibition by antimicrobials. One of these strategies is the enzymatic modification of the antibiotic, in a process generally termed inactivation. Furthermore, some microorganisms may not be limited to the mere inactivation of the antimicrobial compounds. They can continue by further enzymatic degradation of the compounds' carbon backbone, taking nutritional and energetic advantage of the former antibiotic. This driving force to harness an additional food source in a complex environment adds another level of complexity to the reasonably well‐understood process of antibiotic resistance proliferation on a single cell level: It brings bioprotection into play at the level of microbial community. Despite the possible implications of a resistant community in a host and a lurking antibiotic failure, knowledge of degradation pathways of antibiotics and their connections is scarce. Currently, it is limited to only a few families of antibiotics (e.g. β‐lactams and sulfonamides). In this article, we discuss the fluctuating nature of the relationship between antibiotic resistance and the biodegradation of antibiotics. This distinction mainly depends on the genetic background of the microbe, as general resistance genes can be recruited to function in a biodegradation pathway. John Wiley & Sons, Inc. 2020-04-28 2020-07 /pmc/articles/PMC7383678/ /pubmed/32286010 http://dx.doi.org/10.1111/1462-2920.15018 Text en © 2020 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Opinion
Perri, Riccardo
Kolvenbach, Boris A.
Corvini, Philippe F. X.
Subsistence and complexity of antimicrobial resistance on a community‐wide level
title Subsistence and complexity of antimicrobial resistance on a community‐wide level
title_full Subsistence and complexity of antimicrobial resistance on a community‐wide level
title_fullStr Subsistence and complexity of antimicrobial resistance on a community‐wide level
title_full_unstemmed Subsistence and complexity of antimicrobial resistance on a community‐wide level
title_short Subsistence and complexity of antimicrobial resistance on a community‐wide level
title_sort subsistence and complexity of antimicrobial resistance on a community‐wide level
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383678/
https://www.ncbi.nlm.nih.gov/pubmed/32286010
http://dx.doi.org/10.1111/1462-2920.15018
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