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Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate

In this paper, we study the dynamics of an infectious disease in the presence of a continuous-imperfect vaccine and latent period. We consider a general incidence rate function with a non-monotonicity property to interpret the psychological effect in the susceptible population. After we propose the...

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Autor principal: Al-Darabsah, Isam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383700/
https://www.ncbi.nlm.nih.gov/pubmed/32836815
http://dx.doi.org/10.1007/s11071-020-05825-x
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author Al-Darabsah, Isam
author_facet Al-Darabsah, Isam
author_sort Al-Darabsah, Isam
collection PubMed
description In this paper, we study the dynamics of an infectious disease in the presence of a continuous-imperfect vaccine and latent period. We consider a general incidence rate function with a non-monotonicity property to interpret the psychological effect in the susceptible population. After we propose the model, we provide the well-posedness property and calculate the effective reproduction number [Formula: see text] . Then, we obtain the threshold dynamics of the system with respect to [Formula: see text] by studying the global stability of the disease-free equilibrium when [Formula: see text] and the system persistence when [Formula: see text] . For the endemic equilibrium, we use the semi-discretization method to analyze its linear stability. Then, we discuss the critical vaccination coverage rate that is required to eliminate the disease. Numerical simulations are provided to implement a case study regarding data of influenza patients, study the local and global sensitivity of [Formula: see text] , construct approximate stability charts for the endemic equilibrium over different parameter spaces and explore the sensitivity of the proposed model solutions.
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spelling pubmed-73837002020-07-28 Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate Al-Darabsah, Isam Nonlinear Dyn Original Paper In this paper, we study the dynamics of an infectious disease in the presence of a continuous-imperfect vaccine and latent period. We consider a general incidence rate function with a non-monotonicity property to interpret the psychological effect in the susceptible population. After we propose the model, we provide the well-posedness property and calculate the effective reproduction number [Formula: see text] . Then, we obtain the threshold dynamics of the system with respect to [Formula: see text] by studying the global stability of the disease-free equilibrium when [Formula: see text] and the system persistence when [Formula: see text] . For the endemic equilibrium, we use the semi-discretization method to analyze its linear stability. Then, we discuss the critical vaccination coverage rate that is required to eliminate the disease. Numerical simulations are provided to implement a case study regarding data of influenza patients, study the local and global sensitivity of [Formula: see text] , construct approximate stability charts for the endemic equilibrium over different parameter spaces and explore the sensitivity of the proposed model solutions. Springer Netherlands 2020-07-27 2020 /pmc/articles/PMC7383700/ /pubmed/32836815 http://dx.doi.org/10.1007/s11071-020-05825-x Text en © Springer Nature B.V. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Al-Darabsah, Isam
Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title_full Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title_fullStr Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title_full_unstemmed Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title_short Threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
title_sort threshold dynamics of a time-delayed epidemic model for continuous imperfect-vaccine with a generalized nonmonotone incidence rate
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383700/
https://www.ncbi.nlm.nih.gov/pubmed/32836815
http://dx.doi.org/10.1007/s11071-020-05825-x
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