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Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study

OBJECTIVES: The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the relationship between lipid profiles and brachial–ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness. METHODS: A total of 909 participants aged 24...

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Autores principales: Wang, Long, Zhi, Fu, Gao, Beibei, Ni, Jie, Liu, Yihai, Mo, Xuming, Huang, Jinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383716/
https://www.ncbi.nlm.nih.gov/pubmed/32705926
http://dx.doi.org/10.1177/0300060520938188
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author Wang, Long
Zhi, Fu
Gao, Beibei
Ni, Jie
Liu, Yihai
Mo, Xuming
Huang, Jinyu
author_facet Wang, Long
Zhi, Fu
Gao, Beibei
Ni, Jie
Liu, Yihai
Mo, Xuming
Huang, Jinyu
author_sort Wang, Long
collection PubMed
description OBJECTIVES: The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the relationship between lipid profiles and brachial–ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness. METHODS: A total of 909 participants aged 24 to 84 years were stratified into four baPWV quartiles in our study. Serum lipids, baPWV, and other variables of the participants were measured. Univariable and multivariable linear regression analyses were used to examine the relationships between lipid parameters and baPWV. RESULTS: The highest baPWV quartile group had higher aspartate transaminase, alanine aminotransferase, plasma glucose, total cholesterol, triglyceride (TG), and low-density lipoprotein cholesterol levels and maximum ankle–brachial index, and lower high-density lipoprotein cholesterol levels and estimated glomerular filtration rate. Univariate regression analysis showed that total cholesterol, TG, and low-density lipoprotein cholesterol levels were positively related and high-density lipoprotein cholesterol levels were negatively related to baPWV. After adjusting for age, body mass index, smoking status, aspartate transaminase, alanine aminotransferase, plasma glucose, and estimated glomerular filtration rate, only TG levels were correlated with baPWV (β = 0.075). CONCLUSIONS: Four lipid variates are associated with arterial stiffness, and TG levels are positively related to arterial stiffness, independent of cardiovascular risks and liver function.
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spelling pubmed-73837162020-08-10 Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study Wang, Long Zhi, Fu Gao, Beibei Ni, Jie Liu, Yihai Mo, Xuming Huang, Jinyu J Int Med Res Retrospective Clinical Research Report OBJECTIVES: The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the relationship between lipid profiles and brachial–ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness. METHODS: A total of 909 participants aged 24 to 84 years were stratified into four baPWV quartiles in our study. Serum lipids, baPWV, and other variables of the participants were measured. Univariable and multivariable linear regression analyses were used to examine the relationships between lipid parameters and baPWV. RESULTS: The highest baPWV quartile group had higher aspartate transaminase, alanine aminotransferase, plasma glucose, total cholesterol, triglyceride (TG), and low-density lipoprotein cholesterol levels and maximum ankle–brachial index, and lower high-density lipoprotein cholesterol levels and estimated glomerular filtration rate. Univariate regression analysis showed that total cholesterol, TG, and low-density lipoprotein cholesterol levels were positively related and high-density lipoprotein cholesterol levels were negatively related to baPWV. After adjusting for age, body mass index, smoking status, aspartate transaminase, alanine aminotransferase, plasma glucose, and estimated glomerular filtration rate, only TG levels were correlated with baPWV (β = 0.075). CONCLUSIONS: Four lipid variates are associated with arterial stiffness, and TG levels are positively related to arterial stiffness, independent of cardiovascular risks and liver function. SAGE Publications 2020-07-24 /pmc/articles/PMC7383716/ /pubmed/32705926 http://dx.doi.org/10.1177/0300060520938188 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Wang, Long
Zhi, Fu
Gao, Beibei
Ni, Jie
Liu, Yihai
Mo, Xuming
Huang, Jinyu
Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title_full Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title_fullStr Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title_full_unstemmed Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title_short Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
title_sort association between lipid profiles and arterial stiffness: a secondary analysis based on a cross-sectional study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383716/
https://www.ncbi.nlm.nih.gov/pubmed/32705926
http://dx.doi.org/10.1177/0300060520938188
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