Cargando…
Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles
In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO(2)-Ag(2)O nanoparticles by sol-gel method. The nanoparticles were a...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383718/ https://www.ncbi.nlm.nih.gov/pubmed/32782447 http://dx.doi.org/10.1177/1559325820941374 |
_version_ | 1783563477709750272 |
---|---|
author | Ayanwale, Ayodeji Precious Ruíz-Baltazar, Alvaro de Jesús Espinoza-Cristóbal, León Reyes-López, Simón Yobanny |
author_facet | Ayanwale, Ayodeji Precious Ruíz-Baltazar, Alvaro de Jesús Espinoza-Cristóbal, León Reyes-López, Simón Yobanny |
author_sort | Ayanwale, Ayodeji Precious |
collection | PubMed |
description | In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO(2)-Ag(2)O nanoparticles by sol-gel method. The nanoparticles were analyzed and tested for their antibacterial activity against gram-positive bacteria of Bacillus subtilis, Streptococcus mutans, Staphylococcus aureus, and gram-negative of Escherichia coli, Pseudomonas aeruginosa, and Klebsiella oxytoca. X-ray diffraction showed the monoclinic ZrO(2), cubic Ag(2)O, and peaks corresponding to ZrO(2) and Ag(2)O in their mixed samples. Scanning electron microscopy showed spherically shaped nanoparticles while dynamic light scattering analysis showed ZrO(2) (76 nm), Ag(2)O (50 nm), and ZrO(2)-Ag(2)O samples between 14 and 42 nm. The Fourier Transformed Infrared spectroscopy spectra of ZrO(2) gave bands at 480 cm(−1) to 750 cm(−1) (M-O stretching) with Ag(2)O at 580 cm(−1), while ZrO(2)-Ag(2)O samples showed bands at 760 cm(−1). The screening by agar diffusion assay revealed a pronounced increase in the antibacterial activity of ZrO(2)-Ag(2)O against all the tested bacteria when compared with the pure ZrO(2) and Ag(2)O. The improved antibacterial activity of ZrO(2)-Ag(2)O largely results from the chemical stability conferred on it by the ZrO(2) as observed from the zeta potential measurement. |
format | Online Article Text |
id | pubmed-7383718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-73837182020-08-10 Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles Ayanwale, Ayodeji Precious Ruíz-Baltazar, Alvaro de Jesús Espinoza-Cristóbal, León Reyes-López, Simón Yobanny Dose Response Nanotechnology and Microtechnology in Drug Delivery System In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO(2)-Ag(2)O nanoparticles by sol-gel method. The nanoparticles were analyzed and tested for their antibacterial activity against gram-positive bacteria of Bacillus subtilis, Streptococcus mutans, Staphylococcus aureus, and gram-negative of Escherichia coli, Pseudomonas aeruginosa, and Klebsiella oxytoca. X-ray diffraction showed the monoclinic ZrO(2), cubic Ag(2)O, and peaks corresponding to ZrO(2) and Ag(2)O in their mixed samples. Scanning electron microscopy showed spherically shaped nanoparticles while dynamic light scattering analysis showed ZrO(2) (76 nm), Ag(2)O (50 nm), and ZrO(2)-Ag(2)O samples between 14 and 42 nm. The Fourier Transformed Infrared spectroscopy spectra of ZrO(2) gave bands at 480 cm(−1) to 750 cm(−1) (M-O stretching) with Ag(2)O at 580 cm(−1), while ZrO(2)-Ag(2)O samples showed bands at 760 cm(−1). The screening by agar diffusion assay revealed a pronounced increase in the antibacterial activity of ZrO(2)-Ag(2)O against all the tested bacteria when compared with the pure ZrO(2) and Ag(2)O. The improved antibacterial activity of ZrO(2)-Ag(2)O largely results from the chemical stability conferred on it by the ZrO(2) as observed from the zeta potential measurement. SAGE Publications 2020-07-24 /pmc/articles/PMC7383718/ /pubmed/32782447 http://dx.doi.org/10.1177/1559325820941374 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Nanotechnology and Microtechnology in Drug Delivery System Ayanwale, Ayodeji Precious Ruíz-Baltazar, Alvaro de Jesús Espinoza-Cristóbal, León Reyes-López, Simón Yobanny Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title | Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title_full | Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title_fullStr | Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title_full_unstemmed | Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title_short | Bactericidal Activity Study of ZrO(2)-Ag(2)O Nanoparticles |
title_sort | bactericidal activity study of zro(2)-ag(2)o nanoparticles |
topic | Nanotechnology and Microtechnology in Drug Delivery System |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383718/ https://www.ncbi.nlm.nih.gov/pubmed/32782447 http://dx.doi.org/10.1177/1559325820941374 |
work_keys_str_mv | AT ayanwaleayodejiprecious bactericidalactivitystudyofzro2ag2onanoparticles AT ruizbaltazaralvarodejesus bactericidalactivitystudyofzro2ag2onanoparticles AT espinozacristoballeon bactericidalactivitystudyofzro2ag2onanoparticles AT reyeslopezsimonyobanny bactericidalactivitystudyofzro2ag2onanoparticles |