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Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

[Image: see text] The leishmaniases, caused by Leishmania species of protozoan parasites, are neglected tropical diseases with millions of cases worldwide. Current therapeutic approaches are limited by toxicity, resistance, and cost. N-Myristoyltransferase (NMT), an enzyme ubiquitous and essential i...

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Detalles Bibliográficos
Autores principales:	Bell, Andrew S., Yu, Zhiyong, Hutton, Jennie A., Wright, Megan H., Brannigan, James A., Paape, Daniel, Roberts, Shirley M., Sutherell, Charlotte L., Ritzefeld, Markus, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383931/ https://www.ncbi.nlm.nih.gov/pubmed/32575985 http://dx.doi.org/10.1021/acs.jmedchem.0c00570

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