π‐Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Free base, zinc and palladium π‐extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram‐positive bacteria, was found to depend...

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Detalles Bibliográficos
Autores principales: Galstyan, Anzhela, Maurya, Yogesh Kumar, Zhylitskaya, Halina, Bae, Youn Jue, Wu, Yi‐Lin, Wasielewski, Michael R., Lis, Tadeusz, Dobrindt, Ulrich, Stępień, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384002/
https://www.ncbi.nlm.nih.gov/pubmed/31968144
http://dx.doi.org/10.1002/chem.201905372
Descripción
Sumario:Free base, zinc and palladium π‐extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram‐positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.

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