Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200

BACKGROUND: BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis in cynomolgus monkeys. It is being developed for secondary prevention of arterial thrombosis such as stroke or myocardial infarction...

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Detalles Bibliográficos
Autores principales: Zhu, Shuhao, Gilbert, James C., Liang, Zicai, Kang, Daiwu, Li, Ming, Tarantino, Paul M., Jilma, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
THROMBOSIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384040/
https://www.ncbi.nlm.nih.gov/pubmed/32275107
http://dx.doi.org/10.1111/jth.14822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384040/
https://www.ncbi.nlm.nih.gov/pubmed/32275107
http://dx.doi.org/10.1111/jth.14822

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