The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample

Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier and XA reports aim to optimize the understanding of these cont...

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Autores principales: Krane, Jeffrey F., Cibas, Edmund S., Endo, Mayumi, Marqusee, Ellen, Hu, Mimi I., Nasr, Christian E., Waguespack, Steven G., Wirth, Lori J., Kloos, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384066/
https://www.ncbi.nlm.nih.gov/pubmed/32543766
http://dx.doi.org/10.1002/cncy.22300
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author Krane, Jeffrey F.
Cibas, Edmund S.
Endo, Mayumi
Marqusee, Ellen
Hu, Mimi I.
Nasr, Christian E.
Waguespack, Steven G.
Wirth, Lori J.
Kloos, Richard T.
author_facet Krane, Jeffrey F.
Cibas, Edmund S.
Endo, Mayumi
Marqusee, Ellen
Hu, Mimi I.
Nasr, Christian E.
Waguespack, Steven G.
Wirth, Lori J.
Kloos, Richard T.
author_sort Krane, Jeffrey F.
collection PubMed
description Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier and XA reports aim to optimize the understanding of these contributions, including decisions about observation versus surgery, the need for disease‐specific preoperative testing, associated neoplasm types, prognostics, the identification of molecular targets for systemic therapy, and the recognition of potential hereditary syndromes.
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spelling pubmed-73840662020-07-28 The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample Krane, Jeffrey F. Cibas, Edmund S. Endo, Mayumi Marqusee, Ellen Hu, Mimi I. Nasr, Christian E. Waguespack, Steven G. Wirth, Lori J. Kloos, Richard T. Cancer Cytopathol Commentaries Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier and XA reports aim to optimize the understanding of these contributions, including decisions about observation versus surgery, the need for disease‐specific preoperative testing, associated neoplasm types, prognostics, the identification of molecular targets for systemic therapy, and the recognition of potential hereditary syndromes. John Wiley and Sons Inc. 2020-06-16 2020-07 /pmc/articles/PMC7384066/ /pubmed/32543766 http://dx.doi.org/10.1002/cncy.22300 Text en © 2020 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Krane, Jeffrey F.
Cibas, Edmund S.
Endo, Mayumi
Marqusee, Ellen
Hu, Mimi I.
Nasr, Christian E.
Waguespack, Steven G.
Wirth, Lori J.
Kloos, Richard T.
The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title_full The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title_fullStr The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title_full_unstemmed The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title_short The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
title_sort afirma xpression atlas for thyroid nodules and thyroid cancer metastases: insights to inform clinical decision‐making from a fine‐needle aspiration sample
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384066/
https://www.ncbi.nlm.nih.gov/pubmed/32543766
http://dx.doi.org/10.1002/cncy.22300
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