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Randomised clinical trial: linaclotide vs placebo—a study of bi‐directional gut and brain axis
BACKGROUND: Linaclotide, a guanylate cyclase C agonist relieves irritable bowel syndrome with predominant constipation (IBS‐C) symptoms, but how it improves pain in humans is unknown. AIMS: To investigate the effects of linaclotide and placebo on the afferent and efferent gut‐brain‐gut signalling in...
Autores principales: | Rao, Satish S.C., Xiang, Xuelian, Yan, Yun, Rattanakovit, Kulthep, Patcharatrakul, Tanisa, Parr, Rachael, Ayyala, Deepak, Sharma, Amol |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384154/ https://www.ncbi.nlm.nih.gov/pubmed/32406112 http://dx.doi.org/10.1111/apt.15772 |
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