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Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn’s disease and active smoking status resulting in ileal stenosis requiring surgery

BACKGROUND: NOD2 variants are the strongest genetic predictors for susceptibility to Crohn’s disease (CD). However, the clinical value of NOD2 on an individual patient level remains controversial. We aimed to define the predictive power of the major NOD2 mutations regarding complicated CD in a large...

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Detalles Bibliográficos
Autores principales:	Schnitzler, Fabian, Friedrich, Matthias, Angelberger, Marianne, Diegelmann, Julia, Stallhofer, Johannes, Wolf, Christiane, Dütschler, Joel, Truniger, Samuel, Olszak, Torsten, Beigel, Florian, Tillack, Cornelia, Lohse, Peter, Brand, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384669/ https://www.ncbi.nlm.nih.gov/pubmed/32716958 http://dx.doi.org/10.1371/journal.pone.0236421

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