Dissecting distinct proteolytic activities of FMDV L(pro) implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β) gene transcription. Multiple proteins in this signaling pathway (e.g. RIG-I, MDA5, MAVS, TBK1, IRF3...

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Detalles Bibliográficos
Autores principales: Visser, Linda J., Aloise, Chiara, Swatek, Kirby N., Medina, Gisselle N., Olek, Karin M., Rabouw, Huib H., de Groot, Raoul J., Langereis, Martijn A., de los Santos, Teresa, Komander, David, Skern, Tim, van Kuppeveld, Frank J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384677/
https://www.ncbi.nlm.nih.gov/pubmed/32667958
http://dx.doi.org/10.1371/journal.ppat.1008702

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