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Inhibition of pyruvate dehydrogenase kinase-1 by dicoumarol enhances the sensitivity of hepatocellular carcinoma cells to oxaliplatin via metabolic reprogramming

The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of...

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Detalles Bibliográficos
Autores principales:	Xu, Huadan, He, Yichun, Ma, Jiaoyan, Zhao, Yuanxin, Liu, Yanan, Sun, Liankun, Su, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384842/ https://www.ncbi.nlm.nih.gov/pubmed/32705170 http://dx.doi.org/10.3892/ijo.2020.5098

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