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Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
A.I. Gordeyev
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385089/ https://www.ncbi.nlm.nih.gov/pubmed/32742729 http://dx.doi.org/10.32607/actanaturae.10915 |
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author | Konovalov, N. A. Asyutin, D. S. Shayhaev, E. G. Kaprovoy, S. V. Timonin, S. Yu. |
author_facet | Konovalov, N. A. Asyutin, D. S. Shayhaev, E. G. Kaprovoy, S. V. Timonin, S. Yu. |
author_sort | Konovalov, N. A. |
collection | PubMed |
description | A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors. Despite our extensive knowledge regarding IDH mutations in intracranial tumors, mutations of this gene in spinal cord astrocytomas remain poorly understood. In this study, we report on five cases of identified mutations in the IDH1 gene in spinal cord astrocytoma cells, two of which are unique, as they have never been previously described in CNS gliomas. |
format | Online Article Text |
id | pubmed-7385089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | A.I. Gordeyev |
record_format | MEDLINE/PubMed |
spelling | pubmed-73850892020-07-31 Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas Konovalov, N. A. Asyutin, D. S. Shayhaev, E. G. Kaprovoy, S. V. Timonin, S. Yu. Acta Naturae Research Article A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors. Despite our extensive knowledge regarding IDH mutations in intracranial tumors, mutations of this gene in spinal cord astrocytomas remain poorly understood. In this study, we report on five cases of identified mutations in the IDH1 gene in spinal cord astrocytoma cells, two of which are unique, as they have never been previously described in CNS gliomas. A.I. Gordeyev 2020 /pmc/articles/PMC7385089/ /pubmed/32742729 http://dx.doi.org/10.32607/actanaturae.10915 Text en Copyright ® 2020 National Research University Higher School of Economics. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Konovalov, N. A. Asyutin, D. S. Shayhaev, E. G. Kaprovoy, S. V. Timonin, S. Yu. Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title | Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title_full | Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title_fullStr | Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title_full_unstemmed | Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title_short | Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas |
title_sort | rare cases of idh1 mutations in spinal cord astrocytomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385089/ https://www.ncbi.nlm.nih.gov/pubmed/32742729 http://dx.doi.org/10.32607/actanaturae.10915 |
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