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Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas

A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors...

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Autores principales: Konovalov, N. A., Asyutin, D. S., Shayhaev, E. G., Kaprovoy, S. V., Timonin, S. Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385089/
https://www.ncbi.nlm.nih.gov/pubmed/32742729
http://dx.doi.org/10.32607/actanaturae.10915
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author Konovalov, N. A.
Asyutin, D. S.
Shayhaev, E. G.
Kaprovoy, S. V.
Timonin, S. Yu.
author_facet Konovalov, N. A.
Asyutin, D. S.
Shayhaev, E. G.
Kaprovoy, S. V.
Timonin, S. Yu.
author_sort Konovalov, N. A.
collection PubMed
description A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors. Despite our extensive knowledge regarding IDH mutations in intracranial tumors, mutations of this gene in spinal cord astrocytomas remain poorly understood. In this study, we report on five cases of identified mutations in the IDH1 gene in spinal cord astrocytoma cells, two of which are unique, as they have never been previously described in CNS gliomas.
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spelling pubmed-73850892020-07-31 Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas Konovalov, N. A. Asyutin, D. S. Shayhaev, E. G. Kaprovoy, S. V. Timonin, S. Yu. Acta Naturae Research Article A low occurrence rate of spinal cord gliomas (4.3% of primary and glial CNS tumors) and the associated difficulties in building statistically significant cohorts of patients considerably slow down the development of effective approaches to the treatment of spinal cord tumors compared to brain tumors. Despite our extensive knowledge regarding IDH mutations in intracranial tumors, mutations of this gene in spinal cord astrocytomas remain poorly understood. In this study, we report on five cases of identified mutations in the IDH1 gene in spinal cord astrocytoma cells, two of which are unique, as they have never been previously described in CNS gliomas. A.I. Gordeyev 2020 /pmc/articles/PMC7385089/ /pubmed/32742729 http://dx.doi.org/10.32607/actanaturae.10915 Text en Copyright ® 2020 National Research University Higher School of Economics. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Konovalov, N. A.
Asyutin, D. S.
Shayhaev, E. G.
Kaprovoy, S. V.
Timonin, S. Yu.
Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title_full Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title_fullStr Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title_full_unstemmed Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title_short Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
title_sort rare cases of idh1 mutations in spinal cord astrocytomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385089/
https://www.ncbi.nlm.nih.gov/pubmed/32742729
http://dx.doi.org/10.32607/actanaturae.10915
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