Cargando…

ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest

Although tyrosine kinase inhibitors have brought significant success in the treatment of chronic myelogenous leukemia, the search for novel molecular targets for the treatment of this disease remains relevant. Earlier, expression of acid-sensing ion channels, ASIC1a, was demonstrated in the chronic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bychkov, M. L., Shulepko, M. A., Vasileva, V. Y., Sudarikova, A. V., Kirpichnikov, M. P., Lyukmanova, E. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	A.I. Gordeyev 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385094/ https://www.ncbi.nlm.nih.gov/pubmed/32742733 http://dx.doi.org/10.32607/actanaturae.10949

Ejemplares similares

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a
por: Bychkov, Maxim, et al.
Publicado: (2020)

Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer
por: Sudarikova, Anastasia V., et al.
Publicado: (2022)

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
por: Bychkov, Maxim, et al.
Publicado: (2019)

Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes
por: Bychkov, M. L., et al.
Publicado: (2022)

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect
por: Sun, Demeng, et al.
Publicado: (2018)

Lynx1 Prevents Long-Term Potentiation Blockade and Reduction of Neuromodulator Expression Caused by Aβ1-42 and JNK Activation
por: Bychkov, M. L., et al.
Publicado: (2018)

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes
por: Bychkov, Maxim L., et al.
Publicado: (2022)

Human SLURP-1 and SLURP-2 Proteins Acting on Nicotinic Acetylcholine Receptors Reduce Proliferation of Human Colorectal Adenocarcinoma HT-29 Cells
por: Lyukmanova, E. N., et al.
Publicado: (2014)

Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor
por: Lyukmanova, E.N., et al.
Publicado: (2009)

Role of Calcium-Activated Potassium Channels in Proliferation, Migration and Invasion of Human Chronic Myeloid Leukemia K562 Cells
por: Vasileva, Valeria Y., et al.
Publicado: (2023)

New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2
por: Paramonov, Alexander S., et al.
Publicado: (2022)

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis
por: Vasileva, Valeria, et al.
Publicado: (2021)

Lipid–Protein Nanodiscs Offer New Perspectives for Structural and Functional Studies of Water-Soluble Membrane-Active Peptides
por: Shenkarev, Z. O., et al.
Publicado: (2014)

N-Terminal Fusion Tags for Effective Production of G-Protein-Coupled Receptors in Bacterial Cell-Free Systems
por: Lyukmanova, E.N., et al.
Publicado: (2012)

Cell Cycle-Dependent Expression of Bk Channels in Human Mesenchymal Endometrial Stem Cells
por: Chubinskiy-Nadezhdin, Vladislav I., et al.
Publicado: (2019)

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors
por: Lyukmanova, E. N., et al.
Publicado: (2016)

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors
por: Paramonov, Alexander S., et al.
Publicado: (2020)

Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells
por: Rodríguez-Lirio, A., et al.
Publicado: (2015)

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2016)

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1
por: Sun, Demeng, et al.
Publicado: (2020)

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells
por: Bai, Xue Tao, et al.
Publicado: (2015)

Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway
por: Chang, Gaomei, et al.
Publicado: (2017)

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
por: Shenkarev, Zakhar O., et al.
Publicado: (2022)

Cell cycle arrest is not senescence
por: Blagosklonny, Mikhail V.
Publicado: (2011)

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain
por: Kulbatskii, Dmitrii, et al.
Publicado: (2021)

CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
por: Liu, Xuejiao, et al.
Publicado: (2016)

Heme Oxygenase-1 Inhibitors Induce Cell Cycle Arrest and Suppress Tumor Growth in Thyroid Cancer Cells
por: Yang, Po-Sheng, et al.
Publicado: (2018)

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts
por: Leontieva, Olga V., et al.
Publicado: (2017)

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
por: Blagosklonny, Mikhail V.
Publicado: (2012)

The cell cycle checkpoint inhibitors in the treatment of leukemias
por: Ghelli Luserna di Rora’, A., et al.
Publicado: (2017)

Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells
por: Suppipat, Koramit, et al.
Publicado: (2012)

Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells
por: Ly, Tony, et al.
Publicado: (2015)

Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

DNA Damage, Cell Cycle Arrest, and Apoptosis Induction Caused by Lead in Human Leukemia Cells
por: Yedjou, Clement G., et al.
Publicado: (2015)

Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of Early Alzheimer Disease
por: Bychkov, Maxim L., et al.
Publicado: (2023)

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead
por: Cristofori-Armstrong, Ben, et al.
Publicado: (2021)

The VeloPix ASIC
por: Poikela, Tuomas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kpceu4obqjqolfm6gm283ntp61