HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors

The pentose phosphate pathway (PPP) plays a critical role in maintaining cellular redox homeostasis in tumor cells and macromolecule biosynthesis. Upregulation of the PPP has been shown in several types of tumor. However, how the PPP is regulated to confer selective growth advantages on drug resista...

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Detalles Bibliográficos
Autores principales: Xu, Kangjing, He, Zhongyuan, Chen, Ming, Wang, Nuofan, Zhang, Diancai, Yang, Li, Xu, Zekuan, Xu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385157/
https://www.ncbi.nlm.nih.gov/pubmed/32719331
http://dx.doi.org/10.1038/s41419-020-02768-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385157/
https://www.ncbi.nlm.nih.gov/pubmed/32719331
http://dx.doi.org/10.1038/s41419-020-02768-4

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