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Mechanisms Underlying Potential Therapeutic Approaches for COVID-19

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine storm inflammation and lung injury, leading to respiratory distress. The transmission of the virus is mediated by human contact. To co...

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Detalles Bibliográficos
Autores principales: Benani, Abdelouaheb, Ben Mkaddem, Sanae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385230/
https://www.ncbi.nlm.nih.gov/pubmed/32793246
http://dx.doi.org/10.3389/fimmu.2020.01841
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author Benani, Abdelouaheb
Ben Mkaddem, Sanae
author_facet Benani, Abdelouaheb
Ben Mkaddem, Sanae
author_sort Benani, Abdelouaheb
collection PubMed
description Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine storm inflammation and lung injury, leading to respiratory distress. The transmission of the virus is mediated by human contact. To control and prevent the spread of this virus, the majority of people worldwide are facing quarantine; patients are being subjected to non-specific treatments under isolation. To prevent and stop the COVID-19 pandemic, several clinical trials are in the pipeline. The current clinical trials either target the intracellular replication and spread of the virus or the cytokine storm inflammation seen in COVID-19 cases during the later stages of the disease. Since both targeting strategies are different, the window drug administration plays a crucial role in the efficacy of the treatment. Here, we review the mechanism underlying SARS-CoV-2 cell infection and potential future therapeutic approaches.
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spelling pubmed-73852302020-08-12 Mechanisms Underlying Potential Therapeutic Approaches for COVID-19 Benani, Abdelouaheb Ben Mkaddem, Sanae Front Immunol Immunology Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine storm inflammation and lung injury, leading to respiratory distress. The transmission of the virus is mediated by human contact. To control and prevent the spread of this virus, the majority of people worldwide are facing quarantine; patients are being subjected to non-specific treatments under isolation. To prevent and stop the COVID-19 pandemic, several clinical trials are in the pipeline. The current clinical trials either target the intracellular replication and spread of the virus or the cytokine storm inflammation seen in COVID-19 cases during the later stages of the disease. Since both targeting strategies are different, the window drug administration plays a crucial role in the efficacy of the treatment. Here, we review the mechanism underlying SARS-CoV-2 cell infection and potential future therapeutic approaches. Frontiers Media S.A. 2020-07-21 /pmc/articles/PMC7385230/ /pubmed/32793246 http://dx.doi.org/10.3389/fimmu.2020.01841 Text en Copyright © 2020 Benani and Ben Mkaddem. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Benani, Abdelouaheb
Ben Mkaddem, Sanae
Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title_full Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title_fullStr Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title_full_unstemmed Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title_short Mechanisms Underlying Potential Therapeutic Approaches for COVID-19
title_sort mechanisms underlying potential therapeutic approaches for covid-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385230/
https://www.ncbi.nlm.nih.gov/pubmed/32793246
http://dx.doi.org/10.3389/fimmu.2020.01841
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