Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale
Background: Kawasaki disease (KD) is an acute febrile illness that largely affects young children before 5 years of age. Younger children with KD are reported to have a higher prevalence of coronary artery abnormalities. Little is known about infants in the first 3 months of age diagnosed with KD. M...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385248/ https://www.ncbi.nlm.nih.gov/pubmed/32793527 http://dx.doi.org/10.3389/fped.2020.00397 |
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author | Garrido-García, Luis Martín Gutiérrez-Alanis, Juan Humberto Ramírez-Perea, Ana Isabel Tremoulet, Adriana Yamazaki-Nakashimada, Marco Antonio |
author_facet | Garrido-García, Luis Martín Gutiérrez-Alanis, Juan Humberto Ramírez-Perea, Ana Isabel Tremoulet, Adriana Yamazaki-Nakashimada, Marco Antonio |
author_sort | Garrido-García, Luis Martín |
collection | PubMed |
description | Background: Kawasaki disease (KD) is an acute febrile illness that largely affects young children before 5 years of age. Younger children with KD are reported to have a higher prevalence of coronary artery abnormalities. Little is known about infants in the first 3 months of age diagnosed with KD. Methods: A retrospective study was conducted at the National Institute of Pediatrics in Mexico City from 1995 to 2019. Clinical features, laboratory results and cardiac outcomes were recorded. Infants in the first 3 months of age were compared with older patients. Wilcoxon-Mann-Whitney analysis was performed for continuous variables and Fisher's exact test for categorical variables. Results: Six hundred and eighty-eight cases of KD were included in this study. Fourteen cases were diagnosed in the first three months of age. Heart failure and KD shock-syndrome was found in five cases (35.7%). Giant coronary artery aneurysms were found in six cases in the younger group (42.9%). Conclusions: Diagnosis of KD in children younger than 3 months of age is rare. In most cases, an incomplete presentation contributed to a delay diagnosis, treatment, and complications. Younger patients with KD have an increased risk of presenting cardiac complications, including giant coronary artery aneurysms, shock, and death. |
format | Online Article Text |
id | pubmed-7385248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73852482020-08-12 Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale Garrido-García, Luis Martín Gutiérrez-Alanis, Juan Humberto Ramírez-Perea, Ana Isabel Tremoulet, Adriana Yamazaki-Nakashimada, Marco Antonio Front Pediatr Pediatrics Background: Kawasaki disease (KD) is an acute febrile illness that largely affects young children before 5 years of age. Younger children with KD are reported to have a higher prevalence of coronary artery abnormalities. Little is known about infants in the first 3 months of age diagnosed with KD. Methods: A retrospective study was conducted at the National Institute of Pediatrics in Mexico City from 1995 to 2019. Clinical features, laboratory results and cardiac outcomes were recorded. Infants in the first 3 months of age were compared with older patients. Wilcoxon-Mann-Whitney analysis was performed for continuous variables and Fisher's exact test for categorical variables. Results: Six hundred and eighty-eight cases of KD were included in this study. Fourteen cases were diagnosed in the first three months of age. Heart failure and KD shock-syndrome was found in five cases (35.7%). Giant coronary artery aneurysms were found in six cases in the younger group (42.9%). Conclusions: Diagnosis of KD in children younger than 3 months of age is rare. In most cases, an incomplete presentation contributed to a delay diagnosis, treatment, and complications. Younger patients with KD have an increased risk of presenting cardiac complications, including giant coronary artery aneurysms, shock, and death. Frontiers Media S.A. 2020-07-21 /pmc/articles/PMC7385248/ /pubmed/32793527 http://dx.doi.org/10.3389/fped.2020.00397 Text en Copyright © 2020 Garrido-García, Gutiérrez-Alanis, Ramírez-Perea, Tremoulet and Yamazaki-Nakashimada. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Garrido-García, Luis Martín Gutiérrez-Alanis, Juan Humberto Ramírez-Perea, Ana Isabel Tremoulet, Adriana Yamazaki-Nakashimada, Marco Antonio Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title | Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title_full | Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title_fullStr | Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title_full_unstemmed | Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title_short | Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale |
title_sort | kawasaki disease in infants in the first 3 months of age in a mexican population: a cautionary tale |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385248/ https://www.ncbi.nlm.nih.gov/pubmed/32793527 http://dx.doi.org/10.3389/fped.2020.00397 |
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