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Bioactive DNA from extracellular vesicles and particles
Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of molecular biomarkers and mediators of intercellular communication. While most investigations have focused exclusively on the protein, lipid and RNA constituents of these extracellular entities, EV/EP DNA rem...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385258/ https://www.ncbi.nlm.nih.gov/pubmed/32719324 http://dx.doi.org/10.1038/s41419-020-02803-4 |
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author | Malkin, Ethan Z. Bratman, Scott V. |
author_facet | Malkin, Ethan Z. Bratman, Scott V. |
author_sort | Malkin, Ethan Z. |
collection | PubMed |
description | Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of molecular biomarkers and mediators of intercellular communication. While most investigations have focused exclusively on the protein, lipid and RNA constituents of these extracellular entities, EV/EP DNA remains poorly understood, despite DNA being found in association with virtually all EV/EP populations. The functional potential of EV/EP DNA has been proposed in a number of pathological states, including malignancies and autoimmune diseases. Moreover, the effectiveness of cell-free DNA as the biomarker of choice in emerging liquid biopsy applications highlights the role that EV/EP DNA may play as a novel disease biomarker. In this review, we provide a comprehensive overview of EV/EP DNA studies conducted to date, with a particular focus on the roles of EV/EP DNA as a functional mediator and molecular biomarker in various pathologic states. We also review what is currently known about the origins, structure, localisation and distribution of EV/EP DNA, highlighting current controversies as well as opportunities for future investigation. |
format | Online Article Text |
id | pubmed-7385258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73852582020-08-12 Bioactive DNA from extracellular vesicles and particles Malkin, Ethan Z. Bratman, Scott V. Cell Death Dis Review Article Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of molecular biomarkers and mediators of intercellular communication. While most investigations have focused exclusively on the protein, lipid and RNA constituents of these extracellular entities, EV/EP DNA remains poorly understood, despite DNA being found in association with virtually all EV/EP populations. The functional potential of EV/EP DNA has been proposed in a number of pathological states, including malignancies and autoimmune diseases. Moreover, the effectiveness of cell-free DNA as the biomarker of choice in emerging liquid biopsy applications highlights the role that EV/EP DNA may play as a novel disease biomarker. In this review, we provide a comprehensive overview of EV/EP DNA studies conducted to date, with a particular focus on the roles of EV/EP DNA as a functional mediator and molecular biomarker in various pathologic states. We also review what is currently known about the origins, structure, localisation and distribution of EV/EP DNA, highlighting current controversies as well as opportunities for future investigation. Nature Publishing Group UK 2020-07-27 /pmc/articles/PMC7385258/ /pubmed/32719324 http://dx.doi.org/10.1038/s41419-020-02803-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Malkin, Ethan Z. Bratman, Scott V. Bioactive DNA from extracellular vesicles and particles |
title | Bioactive DNA from extracellular vesicles and particles |
title_full | Bioactive DNA from extracellular vesicles and particles |
title_fullStr | Bioactive DNA from extracellular vesicles and particles |
title_full_unstemmed | Bioactive DNA from extracellular vesicles and particles |
title_short | Bioactive DNA from extracellular vesicles and particles |
title_sort | bioactive dna from extracellular vesicles and particles |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385258/ https://www.ncbi.nlm.nih.gov/pubmed/32719324 http://dx.doi.org/10.1038/s41419-020-02803-4 |
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