Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Aging leads to changes in nearly all pharmacokinetic phases. Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dose proportionality following oral administration in aged individuals remains unknown. Herein, we established a...

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Detalles Bibliográficos
Autores principales: Ye, Li-Xiang, Xu, Ying, Zhang, Shui-Hua, Cao, Da-Xuan, Chen, Ling-Fan, Su, Yan-Ping, Huang, Hui-Hui, Yu, Chang-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385321/
https://www.ncbi.nlm.nih.gov/pubmed/32792950
http://dx.doi.org/10.3389/fphar.2020.01113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385321/
https://www.ncbi.nlm.nih.gov/pubmed/32792950
http://dx.doi.org/10.3389/fphar.2020.01113

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