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EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling
ETS homologous factor (EHF) plays a critical function in epithelial cell differentiation and proliferation. However, the roles of EHF in cancer remain largely unknown. In the present study, we investigated the expression levels, precise function and mechanism of EHF in colorectal carcinoma (CRC). We...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385339/ https://www.ncbi.nlm.nih.gov/pubmed/32372436 http://dx.doi.org/10.1111/cas.14444 |
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author | Wang, Lan Ai, Meiling Nie, Miaoting Zhao, Li Deng, Guangxu Hu, Shasha Han, Yue Zeng, Weiting Wang, Yiqing Yang, Minhui Wang, Shuang |
author_facet | Wang, Lan Ai, Meiling Nie, Miaoting Zhao, Li Deng, Guangxu Hu, Shasha Han, Yue Zeng, Weiting Wang, Yiqing Yang, Minhui Wang, Shuang |
author_sort | Wang, Lan |
collection | PubMed |
description | ETS homologous factor (EHF) plays a critical function in epithelial cell differentiation and proliferation. However, the roles of EHF in cancer remain largely unknown. In the present study, we investigated the expression levels, precise function and mechanism of EHF in colorectal carcinoma (CRC). We observed significantly elevated EHF expression in CRC cell lines and tissues. EHF overexpression correlated positively with poor differentiation, advanced T stage, and shorter overall survival of CRC patients. Function experiments revealed that EHF overexpression promoted CRC cell proliferation, migration, and invasion in vitro and in vivo. Mechanistically, EHF could directly upregulate transforming growth factor β1 (TGF‐β1) expression at the transcription level, thereby activating canonical TGF‐β signaling. Our findings provide novel insights into the mechanisms of EHF in tumorigenesis, invasion, and metastasis of CRC, which may help to provide new therapeutic targets for CRC intervention. |
format | Online Article Text |
id | pubmed-7385339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73853392020-07-30 EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling Wang, Lan Ai, Meiling Nie, Miaoting Zhao, Li Deng, Guangxu Hu, Shasha Han, Yue Zeng, Weiting Wang, Yiqing Yang, Minhui Wang, Shuang Cancer Sci Original Articles ETS homologous factor (EHF) plays a critical function in epithelial cell differentiation and proliferation. However, the roles of EHF in cancer remain largely unknown. In the present study, we investigated the expression levels, precise function and mechanism of EHF in colorectal carcinoma (CRC). We observed significantly elevated EHF expression in CRC cell lines and tissues. EHF overexpression correlated positively with poor differentiation, advanced T stage, and shorter overall survival of CRC patients. Function experiments revealed that EHF overexpression promoted CRC cell proliferation, migration, and invasion in vitro and in vivo. Mechanistically, EHF could directly upregulate transforming growth factor β1 (TGF‐β1) expression at the transcription level, thereby activating canonical TGF‐β signaling. Our findings provide novel insights into the mechanisms of EHF in tumorigenesis, invasion, and metastasis of CRC, which may help to provide new therapeutic targets for CRC intervention. John Wiley and Sons Inc. 2020-06-10 2020-07 /pmc/articles/PMC7385339/ /pubmed/32372436 http://dx.doi.org/10.1111/cas.14444 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Wang, Lan Ai, Meiling Nie, Miaoting Zhao, Li Deng, Guangxu Hu, Shasha Han, Yue Zeng, Weiting Wang, Yiqing Yang, Minhui Wang, Shuang EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title | EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title_full | EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title_fullStr | EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title_full_unstemmed | EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title_short | EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling |
title_sort | ehf promotes colorectal carcinoma progression by activating tgf‐β1 transcription and canonical tgf‐β signaling |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385339/ https://www.ncbi.nlm.nih.gov/pubmed/32372436 http://dx.doi.org/10.1111/cas.14444 |
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