Cargando…
Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunoge...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385486/ https://www.ncbi.nlm.nih.gov/pubmed/32793398 http://dx.doi.org/10.1038/s41541-020-00221-3 |
| _version_ | 1783563795051839488 |
|---|---|
| author | Graham, Simon P. McLean, Rebecca K. Spencer, Alexandra J. Belij-Rammerstorfer, Sandra Wright, Daniel Ulaszewska, Marta Edwards, Jane C. Hayes, Jack W. P. Martini, Veronica Thakur, Nazia Conceicao, Carina Dietrich, Isabelle Shelton, Holly Waters, Ryan Ludi, Anna Wilsden, Ginette Browning, Clare Bialy, Dagmara Bhat, Sushant Stevenson-Leggett, Phoebe Hollinghurst, Philippa Gilbride, Ciaran Pulido, David Moffat, Katy Sharpe, Hannah Allen, Elizabeth Mioulet, Valerie Chiu, Chris Newman, Joseph Asfor, Amin S. Burman, Alison Crossley, Sylvia Huo, Jiandong Owens, Raymond J. Carroll, Miles Hammond, John A. Tchilian, Elma Bailey, Dalan Charleston, Bryan Gilbert, Sarah C. Tuthill, Tobias J. Lambe, Teresa |
| author_facet | Graham, Simon P. McLean, Rebecca K. Spencer, Alexandra J. Belij-Rammerstorfer, Sandra Wright, Daniel Ulaszewska, Marta Edwards, Jane C. Hayes, Jack W. P. Martini, Veronica Thakur, Nazia Conceicao, Carina Dietrich, Isabelle Shelton, Holly Waters, Ryan Ludi, Anna Wilsden, Ginette Browning, Clare Bialy, Dagmara Bhat, Sushant Stevenson-Leggett, Phoebe Hollinghurst, Philippa Gilbride, Ciaran Pulido, David Moffat, Katy Sharpe, Hannah Allen, Elizabeth Mioulet, Valerie Chiu, Chris Newman, Joseph Asfor, Amin S. Burman, Alison Crossley, Sylvia Huo, Jiandong Owens, Raymond J. Carroll, Miles Hammond, John A. Tchilian, Elma Bailey, Dalan Charleston, Bryan Gilbert, Sarah C. Tuthill, Tobias J. Lambe, Teresa |
| author_sort | Graham, Simon P. |
| collection | PubMed |
| description | Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres. |
| format | Online Article Text |
| id | pubmed-7385486 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73854862020-08-12 Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 Graham, Simon P. McLean, Rebecca K. Spencer, Alexandra J. Belij-Rammerstorfer, Sandra Wright, Daniel Ulaszewska, Marta Edwards, Jane C. Hayes, Jack W. P. Martini, Veronica Thakur, Nazia Conceicao, Carina Dietrich, Isabelle Shelton, Holly Waters, Ryan Ludi, Anna Wilsden, Ginette Browning, Clare Bialy, Dagmara Bhat, Sushant Stevenson-Leggett, Phoebe Hollinghurst, Philippa Gilbride, Ciaran Pulido, David Moffat, Katy Sharpe, Hannah Allen, Elizabeth Mioulet, Valerie Chiu, Chris Newman, Joseph Asfor, Amin S. Burman, Alison Crossley, Sylvia Huo, Jiandong Owens, Raymond J. Carroll, Miles Hammond, John A. Tchilian, Elma Bailey, Dalan Charleston, Bryan Gilbert, Sarah C. Tuthill, Tobias J. Lambe, Teresa NPJ Vaccines Brief Communication Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres. Nature Publishing Group UK 2020-07-27 /pmc/articles/PMC7385486/ /pubmed/32793398 http://dx.doi.org/10.1038/s41541-020-00221-3 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Graham, Simon P. McLean, Rebecca K. Spencer, Alexandra J. Belij-Rammerstorfer, Sandra Wright, Daniel Ulaszewska, Marta Edwards, Jane C. Hayes, Jack W. P. Martini, Veronica Thakur, Nazia Conceicao, Carina Dietrich, Isabelle Shelton, Holly Waters, Ryan Ludi, Anna Wilsden, Ginette Browning, Clare Bialy, Dagmara Bhat, Sushant Stevenson-Leggett, Phoebe Hollinghurst, Philippa Gilbride, Ciaran Pulido, David Moffat, Katy Sharpe, Hannah Allen, Elizabeth Mioulet, Valerie Chiu, Chris Newman, Joseph Asfor, Amin S. Burman, Alison Crossley, Sylvia Huo, Jiandong Owens, Raymond J. Carroll, Miles Hammond, John A. Tchilian, Elma Bailey, Dalan Charleston, Bryan Gilbert, Sarah C. Tuthill, Tobias J. Lambe, Teresa Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title | Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title_full | Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title_fullStr | Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title_full_unstemmed | Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title_short | Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 |
| title_sort | evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored covid-19 vaccine candidate chadox1 ncov-19 |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385486/ https://www.ncbi.nlm.nih.gov/pubmed/32793398 http://dx.doi.org/10.1038/s41541-020-00221-3 |
| work_keys_str_mv | AT grahamsimonp evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT mcleanrebeccak evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT spenceralexandraj evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT belijrammerstorfersandra evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT wrightdaniel evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT ulaszewskamarta evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT edwardsjanec evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT hayesjackwp evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT martiniveronica evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT thakurnazia evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT conceicaocarina evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT dietrichisabelle evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT sheltonholly evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT watersryan evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT ludianna evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT wilsdenginette evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT browningclare evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT bialydagmara evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT bhatsushant evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT stevensonleggettphoebe evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT hollinghurstphilippa evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT gilbrideciaran evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT pulidodavid evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT moffatkaty evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT sharpehannah evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT allenelizabeth evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT miouletvalerie evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT chiuchris evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT newmanjoseph evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT asforamins evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT burmanalison evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT crossleysylvia evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT huojiandong evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT owensraymondj evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT carrollmiles evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT hammondjohna evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT tchilianelma evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT baileydalan evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT charlestonbryan evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT gilbertsarahc evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT tuthilltobiasj evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 AT lambeteresa evaluationoftheimmunogenicityofprimeboostvaccinationwiththereplicationdeficientviralvectoredcovid19vaccinecandidatechadox1ncov19 |