LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome

Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse embryonic stem cells. However, its role in adult intestinal stem cells (ISCs) is unclear. The adult intestinal epithelium has a high self-renewal rate driven by ISCs in crypts. Here, we find that LIF is pr...

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Detalles Bibliográficos
Autores principales: Wang, Huaying, Wang, Jianming, Zhao, Yuhan, Zhang, Xiao, Liu, Juan, Zhang, Cen, Haffty, Bruce, Verzi, Michael, Zhang, Lanjing, Gao, Nan, Feng, Zhaohui, Hu, Wenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385639/
https://www.ncbi.nlm.nih.gov/pubmed/32719388
http://dx.doi.org/10.1038/s41419-020-02790-6

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