Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY

Activation of κ opioid receptor (KOR) produces analgesia, antipruritic effect, sedation and dysphoria. To characterize neuroanatomy of KOR at high resolutions and circumvent issues of specificity of KOR antibodies, we generated a knock-in mouse line expressing KOR fused at the C terminus with the fl...

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Detalles Bibliográficos
Autores principales: Chen, Chongguang, Willhouse, Alex H., Huang, Peng, Ko, Nora, Wang, Yujun, Xu, Bin, Huang, Lan Hsuan Melody, Kieffer, Brigitte, Barbe, Mary F., Liu-Chen, Lee-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: Methods/New Tools
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385665/
https://www.ncbi.nlm.nih.gov/pubmed/32561573
http://dx.doi.org/10.1523/ENEURO.0028-20.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385665/
https://www.ncbi.nlm.nih.gov/pubmed/32561573
http://dx.doi.org/10.1523/ENEURO.0028-20.2020

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