In Silico Investigation of First-Pass Effect on Selected Small Molecule Excipients and Structural Dynamics of P-glycoprotein

In this study, the interaction of selected pharmaceutical excipients on the function of P-glycoprotein (P-gp) and activity of 6 cytochrome P450 (CYP) isoforms were computationally investigated. At binding free energy cut-off value of −5.0 kcal/mol, the result showed possible modulatory or inhibitory...

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Detalles Bibliográficos
Autores principales: Fatoki, Toluwase Hezekiah, Ibraheem, Omodele, Awofisayo, Oladoja A, Oyedele, Abiodun Samuel, Akinlolu, Olapade Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385845/
https://www.ncbi.nlm.nih.gov/pubmed/32782427
http://dx.doi.org/10.1177/1177932220943183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385845/
https://www.ncbi.nlm.nih.gov/pubmed/32782427
http://dx.doi.org/10.1177/1177932220943183

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