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The PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in chronic obstructive pulmonary disease caused by PM2.5 particulate matter
OBJECTIVE: Many lung diseases are associated with changes in autophagic activity. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays a key regulatory role in autophagy. Our aim was to explore the function of PI3K/AKT/mTOR path...
Autores principales: | Zhang, Fang, Ma, Hui, Wang, Zhong Lan, Li, Wei Hua, Liu, Hua, Zhao, Yan Xia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385846/ https://www.ncbi.nlm.nih.gov/pubmed/32715876 http://dx.doi.org/10.1177/0300060520927919 |
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