Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sens...

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Detalles Bibliográficos
Autores principales: Prasanth, K. Reddisiva, Hirano, Minato, Fagg, W. Samuel, McAnarney, Eileen T., Shan, Chao, Xie, Xuping, Hage, Adam, Pietzsch, Colette A., Bukreyev, Alexander, Rajsbaum, Ricardo, Shi, Pei-Yong, Bedford, Mark T., Bradrick, Shelton S., Menachery, Vineet, Garcia-Blanco, Mariano A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386308/
https://www.ncbi.nlm.nih.gov/pubmed/32735900
http://dx.doi.org/10.1016/j.antiviral.2020.104874
Descripción
Sumario:Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.

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