Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

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SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp8(2)/nsp12) along with a cast of accessory factors. One of these factors is the nsp13 helicase. Both the holo-RdRp and nsp...

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Detalles Bibliográficos
Autores principales: Chen, James, Malone, Brandon, Llewellyn, Eliza, Grasso, Michael, Shelton, Patrick M.M., Olinares, Paul Dominic B., Maruthi, Kashyap, Eng, Edward T., Vatandaslar, Hasan, Chait, Brian T., Kapoor, Tarun M., Darst, Seth A., Campbell, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386476/
https://www.ncbi.nlm.nih.gov/pubmed/32783916
http://dx.doi.org/10.1016/j.cell.2020.07.033
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