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A deep learning framework for high-throughput mechanism-driven phenotype compound screening

Target-based high-throughput compound screening dominates conventional one-drug-one-gene drug discovery process. However, the readout from the chemical modulation of a single protein is poorly correlated with phenotypic response of organism, leading to high failure rate in drug development. Chemical...

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Detalles Bibliográficos
Autores principales:	Pham, Thai-Hoang, Qiu, Yue, Zeng, Jucheng, Xie, Lei, Zhang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386506/ https://www.ncbi.nlm.nih.gov/pubmed/32743586 http://dx.doi.org/10.1101/2020.07.19.211235

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