Cargando…

A deep learning framework for high-throughput mechanism-driven phenotype compound screening

Target-based high-throughput compound screening dominates conventional one-drug-one-gene drug discovery process. However, the readout from the chemical modulation of a single protein is poorly correlated with phenotypic response of organism, leading to high failure rate in drug development. Chemical...

Descripción completa

Detalles Bibliográficos
Autores principales: Pham, Thai-Hoang, Qiu, Yue, Zeng, Jucheng, Xie, Lei, Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386506/
https://www.ncbi.nlm.nih.gov/pubmed/32743586
http://dx.doi.org/10.1101/2020.07.19.211235

Ejemplares similares