Destination of corpus luteum in postpartum clinical endometritis cows and factors affecting self-recovery

In this study, the fate of corpus luteum was investigated in cows affected by severe clinical endometritis. Also, concentration of IL-1β, IL-6, COX-2, adiponectin, leptin, progesterone (P4), PGFM, insulin, and IGF-1 were studied in severe clinical endometritis cows at day 30 ± 3 postpartum. Eighty-seven dairy cows affected by severe clinical endometritis were selected and their reproductive tract was examined by ultrasonography at day 30 ± 3 postpartum (first examination) and 14 days later (second examination). The majority of the cows with CL and affected by clinical endometritis at first examination had new CL 14 days later, and most of these cows were clean without any treatment (self-healing). The CL of about 28.7% of all cows with clinical endometritis at first examination persisted two weeks later and the uterus of most of them remained infected as pyometric cows. Most of the anestrous cows (83.3%) were pregnant, but only 51% of cows with new CL were pregnant at the end of next six month period. There was a significant difference in the means of lactation number, uterine lumen diameter, cervical diameter, and size of uterine horn, milk production at first examination, concentrations of insulin, COX-2, P4, IL-1β, and IL-6 among persistent CL, new CL, and anestrous cows. The pregnancy rate and the discharge score were different among persistent CL, new CL, and anestrous cows. In conclusion, CL on ovary of cows and its fate could affect recovery from severe clinical endometritis. The concentration of some metabolic hormones influenced the self-recovery of cows from clinical endometritis.