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Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management

Hyponatremia, defined as serum sodium concentration <135 mEq/l, is the most common electrolyte balance disorder in clinical practice. Many causes are listed, but syndrome of inappropriate antidiuretic hormone secretion (SIADH) is certainly the most relevant, mainly in oncological and hospitalized...

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Detalles Bibliográficos
Autores principales: Mentrasti, Giulia, Scortichini, Laura, Torniai, Mariangela, Giampieri, Riccardo, Morgese, Francesca, Rinaldi, Silvia, Berardi, Rossana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386802/
https://www.ncbi.nlm.nih.gov/pubmed/32801723
http://dx.doi.org/10.2147/TCRM.S206066
Descripción
Sumario:Hyponatremia, defined as serum sodium concentration <135 mEq/l, is the most common electrolyte balance disorder in clinical practice. Many causes are listed, but syndrome of inappropriate antidiuretic hormone secretion (SIADH) is certainly the most relevant, mainly in oncological and hospitalized patients. In this review, the pathophysiological and clinical aspects are described in detail. Patients’ extensive medical history and structured physical and biochemical tests are considered the milestones marking the way of the SIADH management as to provide early detection and proper correction. We focused our attention on the poor prognostic role and negative effect on patient’s quality of life of SIADH-induced hyponatremia in both malignant and non-malignant settings, stressing how optimal management of this electrolyte imbalance can result in improved outcomes and lower health costs.