Cargando…
Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin
BACKGROUND AND AIM: Flibanserin (FLB) is a multifunctional serotonergic agent used for treating hypoactive sexual desire disorder in premenopausal women via oral administration. FLB has a reported limited oral bioavailability of 33% that could be attributed to the drug’s first-pass metabolism. In ad...
Autores principales: | Fahmy, Usama A, Ahmed, Osama A A, Badr-Eldin, Shaimaa M, Aldawsari, Hibah M, Okbazghi, Solomon Z, Awan, Zuhier A, Bakhrebah, Muhammed A, Alomary, Mohammad N, Abdulaal, Wesam H, Medina, Carlos, Alhakamy, Nabil A |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386805/ https://www.ncbi.nlm.nih.gov/pubmed/32801690 http://dx.doi.org/10.2147/IJN.S258791 |
Ejemplares similares
-
Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route
por: Ahmed, Osama A. A., et al.
Publicado: (2020) -
Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation
por: Fahmy, Usama A., et al.
Publicado: (2020) -
Green Nanoemulsion Stabilized by In Situ Self-Assembled Natural Oil/Native Cyclodextrin Complexes: An Eco-Friendly Approach for Enhancing Anticancer Activity of Costunolide against Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2022) -
Scorpion Venom-Functionalized Quercetin Phytosomes for Breast Cancer Management: In Vitro Response Surface Optimization and Anticancer Activity against MCF-7 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021) -
Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats
por: Alhakamy, Nabil A., et al.
Publicado: (2020)