A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance

The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et a...

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Detalles Bibliográficos
Autores principales: Goodman, Christopher D, Uddin, Taher, Spillman, Natalie J, McFadden, Geoffrey I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386903/
https://www.ncbi.nlm.nih.gov/pubmed/32678064
http://dx.doi.org/10.7554/eLife.58629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386903/
https://www.ncbi.nlm.nih.gov/pubmed/32678064
http://dx.doi.org/10.7554/eLife.58629

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