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Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity
Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways. Hallmarks of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes and examples of genomic clusteri...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386920/ https://www.ncbi.nlm.nih.gov/pubmed/32613943 http://dx.doi.org/10.7554/eLife.56717 |
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author | Fan, Pengxiang Wang, Peipei Lou, Yann-Ru Leong, Bryan J Moore, Bethany M Schenck, Craig A Combs, Rachel Cao, Pengfei Brandizzi, Federica Shiu, Shin-Han Last, Robert L |
author_facet | Fan, Pengxiang Wang, Peipei Lou, Yann-Ru Leong, Bryan J Moore, Bethany M Schenck, Craig A Combs, Rachel Cao, Pengfei Brandizzi, Federica Shiu, Shin-Han Last, Robert L |
author_sort | Fan, Pengxiang |
collection | PubMed |
description | Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways. Hallmarks of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes and examples of genomic clustering of pathway genes. Solanaceae glandular trichomes produce defensive acylsugars, with sidechains that vary in length across the family. We describe a tomato gene cluster on chromosome 7 involved in medium chain acylsugar accumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes. This cluster co-localizes with a tomato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region containing another acylsugar pathway gene. We reconstructed the evolutionary events leading to this gene cluster and found that its phylogenetic distribution correlates with medium chain acylsugar accumulation across the Solanaceae. This work reveals insights into the dynamics behind gene cluster evolution and cell-type specific metabolite diversity. |
format | Online Article Text |
id | pubmed-7386920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73869202020-07-29 Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity Fan, Pengxiang Wang, Peipei Lou, Yann-Ru Leong, Bryan J Moore, Bethany M Schenck, Craig A Combs, Rachel Cao, Pengfei Brandizzi, Federica Shiu, Shin-Han Last, Robert L eLife Biochemistry and Chemical Biology Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways. Hallmarks of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes and examples of genomic clustering of pathway genes. Solanaceae glandular trichomes produce defensive acylsugars, with sidechains that vary in length across the family. We describe a tomato gene cluster on chromosome 7 involved in medium chain acylsugar accumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes. This cluster co-localizes with a tomato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region containing another acylsugar pathway gene. We reconstructed the evolutionary events leading to this gene cluster and found that its phylogenetic distribution correlates with medium chain acylsugar accumulation across the Solanaceae. This work reveals insights into the dynamics behind gene cluster evolution and cell-type specific metabolite diversity. eLife Sciences Publications, Ltd 2020-07-02 /pmc/articles/PMC7386920/ /pubmed/32613943 http://dx.doi.org/10.7554/eLife.56717 Text en © 2020, Fan et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Biochemistry and Chemical Biology Fan, Pengxiang Wang, Peipei Lou, Yann-Ru Leong, Bryan J Moore, Bethany M Schenck, Craig A Combs, Rachel Cao, Pengfei Brandizzi, Federica Shiu, Shin-Han Last, Robert L Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title | Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title_full | Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title_fullStr | Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title_full_unstemmed | Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title_short | Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity |
title_sort | evolution of a plant gene cluster in solanaceae and emergence of metabolic diversity |
topic | Biochemistry and Chemical Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386920/ https://www.ncbi.nlm.nih.gov/pubmed/32613943 http://dx.doi.org/10.7554/eLife.56717 |
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