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A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019
BACKGROUND: Coronavirus disease 2019 (COVID-19) is highly contagious, and the epidemic has spread to hundreds of countries around the world, and seriously threatens the life safety of people around the world. Arbidol is an antiviral drug with high potential against COVID-19, but evidence of effectiv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386950/ https://www.ncbi.nlm.nih.gov/pubmed/32791753 http://dx.doi.org/10.1097/MD.0000000000021402 |
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author | Wang, Xuemei Xie, Ping Sun, Guojuan Zhao, Min Deng, Zhumei Zhou, Yunxia Bao, Shuting |
author_facet | Wang, Xuemei Xie, Ping Sun, Guojuan Zhao, Min Deng, Zhumei Zhou, Yunxia Bao, Shuting |
author_sort | Wang, Xuemei |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) is highly contagious, and the epidemic has spread to hundreds of countries around the world, and seriously threatens the life safety of people around the world. Arbidol is an antiviral drug with high potential against COVID-19, but evidence of effectiveness and safety is lacking. The systematic review protocol aims to formulate a research plan that can evaluate the efficacy and safety of arbidol for COVID-19. METHODS: The retrieval time will be from the database establishment to June 2020. The retrieval database will include the Cochrane Library, PubMed, Embase, OVID, CNKI, Wanfang, VIP, CBM, etc. The primary outcome will be clinical efficacy, and the secondary results will be accompanying symptoms, time for the temperature to return to normal, time of novel coronavirus nucleic acid turning negative, blood sample test, Computed Tomography examination, length of hospitalization, adverse reactions, and adverse events. RevManV.5.3 software will be used for meta-analysis, and fixed effects model, random-effects model, subgroup analysis, and descriptive analysis will be adopted according to the heterogeneity of the research results. RESULTS: To provide the latest evidence of clinical efficacy and safety of arbidol in the treatment of COVID-19. CONCLUSION: Our study will provide the latest evidence analysis of the efficacy and safety of arbidol for COVID-19, to provide evidence-based medicine for the prevention and control of this epidemic. REGISTRATION DETAILS: PROSPERO CRD42020189203. |
format | Online Article Text |
id | pubmed-7386950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-73869502020-08-05 A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 Wang, Xuemei Xie, Ping Sun, Guojuan Zhao, Min Deng, Zhumei Zhou, Yunxia Bao, Shuting Medicine (Baltimore) 4900 BACKGROUND: Coronavirus disease 2019 (COVID-19) is highly contagious, and the epidemic has spread to hundreds of countries around the world, and seriously threatens the life safety of people around the world. Arbidol is an antiviral drug with high potential against COVID-19, but evidence of effectiveness and safety is lacking. The systematic review protocol aims to formulate a research plan that can evaluate the efficacy and safety of arbidol for COVID-19. METHODS: The retrieval time will be from the database establishment to June 2020. The retrieval database will include the Cochrane Library, PubMed, Embase, OVID, CNKI, Wanfang, VIP, CBM, etc. The primary outcome will be clinical efficacy, and the secondary results will be accompanying symptoms, time for the temperature to return to normal, time of novel coronavirus nucleic acid turning negative, blood sample test, Computed Tomography examination, length of hospitalization, adverse reactions, and adverse events. RevManV.5.3 software will be used for meta-analysis, and fixed effects model, random-effects model, subgroup analysis, and descriptive analysis will be adopted according to the heterogeneity of the research results. RESULTS: To provide the latest evidence of clinical efficacy and safety of arbidol in the treatment of COVID-19. CONCLUSION: Our study will provide the latest evidence analysis of the efficacy and safety of arbidol for COVID-19, to provide evidence-based medicine for the prevention and control of this epidemic. REGISTRATION DETAILS: PROSPERO CRD42020189203. Wolters Kluwer Health 2020-07-24 /pmc/articles/PMC7386950/ /pubmed/32791753 http://dx.doi.org/10.1097/MD.0000000000021402 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | 4900 Wang, Xuemei Xie, Ping Sun, Guojuan Zhao, Min Deng, Zhumei Zhou, Yunxia Bao, Shuting A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title | A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title_full | A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title_fullStr | A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title_full_unstemmed | A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title_short | A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
title_sort | systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019 |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386950/ https://www.ncbi.nlm.nih.gov/pubmed/32791753 http://dx.doi.org/10.1097/MD.0000000000021402 |
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