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Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further lead...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387080/ https://www.ncbi.nlm.nih.gov/pubmed/32837530 http://dx.doi.org/10.1007/s42690-020-00213-9 |
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author | Kumar, Sachin Gupta, Snehil Mohmad, Aquil Fular, Ashutosh Parthasarathi, B. C. Chaubey, Ashok Kumar |
author_facet | Kumar, Sachin Gupta, Snehil Mohmad, Aquil Fular, Ashutosh Parthasarathi, B. C. Chaubey, Ashok Kumar |
author_sort | Kumar, Sachin |
collection | PubMed |
description | The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further leads to the introduction of several purified vaccines in the field of veterinary parasitology. Earlier, the conventional diagnostic methods was entirely based upon morphological taxonomy for diagnosis of parasites but nowadays improved molecular techniques help in phylogenetic study and open an another area of molecular taxonomy of parasites with high precision. Control measures based upon targeting endosymbionts in parasites like Dirofilaria immitis is also under exploration in veterinary parasitology. Metagenomics have added an inside story of parasites bionomics which have created havoc in human and animals population since centuries. Omics era is playing a key role in opening the new approaches on parasite biology. Various newer generations of safer vaccines like edible vaccines and subunit vaccines and diagnostic techniques based upon purified immunologically active epitopes have become commercially available against the parasites (helminths, protozoa and arthropod borne diseases). Nowadays, a transgenic and gene knock out studies using RNA interference and CRISPR are also helping in understanding the functions of genes and screening of target genes, which are not available before the advent of molecular tools. Molecular techniques had paramount impact on increasing the sensitivity of diagnostic tools, epidemiological studies and more importantly in controlling these diseases. This review is about the advancements in veterinary parasitology and their impact on the control of these pathogens. |
format | Online Article Text |
id | pubmed-7387080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73870802020-07-29 Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance Kumar, Sachin Gupta, Snehil Mohmad, Aquil Fular, Ashutosh Parthasarathi, B. C. Chaubey, Ashok Kumar Int J Trop Insect Sci Mini-Review The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further leads to the introduction of several purified vaccines in the field of veterinary parasitology. Earlier, the conventional diagnostic methods was entirely based upon morphological taxonomy for diagnosis of parasites but nowadays improved molecular techniques help in phylogenetic study and open an another area of molecular taxonomy of parasites with high precision. Control measures based upon targeting endosymbionts in parasites like Dirofilaria immitis is also under exploration in veterinary parasitology. Metagenomics have added an inside story of parasites bionomics which have created havoc in human and animals population since centuries. Omics era is playing a key role in opening the new approaches on parasite biology. Various newer generations of safer vaccines like edible vaccines and subunit vaccines and diagnostic techniques based upon purified immunologically active epitopes have become commercially available against the parasites (helminths, protozoa and arthropod borne diseases). Nowadays, a transgenic and gene knock out studies using RNA interference and CRISPR are also helping in understanding the functions of genes and screening of target genes, which are not available before the advent of molecular tools. Molecular techniques had paramount impact on increasing the sensitivity of diagnostic tools, epidemiological studies and more importantly in controlling these diseases. This review is about the advancements in veterinary parasitology and their impact on the control of these pathogens. Springer International Publishing 2020-07-29 2021 /pmc/articles/PMC7387080/ /pubmed/32837530 http://dx.doi.org/10.1007/s42690-020-00213-9 Text en © African Association of Insect Scientists 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Mini-Review Kumar, Sachin Gupta, Snehil Mohmad, Aquil Fular, Ashutosh Parthasarathi, B. C. Chaubey, Ashok Kumar Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title | Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title_full | Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title_fullStr | Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title_full_unstemmed | Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title_short | Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
title_sort | molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387080/ https://www.ncbi.nlm.nih.gov/pubmed/32837530 http://dx.doi.org/10.1007/s42690-020-00213-9 |
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