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Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance

The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further lead...

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Detalles Bibliográficos
Autores principales: Kumar, Sachin, Gupta, Snehil, Mohmad, Aquil, Fular, Ashutosh, Parthasarathi, B. C., Chaubey, Ashok Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387080/
https://www.ncbi.nlm.nih.gov/pubmed/32837530
http://dx.doi.org/10.1007/s42690-020-00213-9
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author Kumar, Sachin
Gupta, Snehil
Mohmad, Aquil
Fular, Ashutosh
Parthasarathi, B. C.
Chaubey, Ashok Kumar
author_facet Kumar, Sachin
Gupta, Snehil
Mohmad, Aquil
Fular, Ashutosh
Parthasarathi, B. C.
Chaubey, Ashok Kumar
author_sort Kumar, Sachin
collection PubMed
description The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further leads to the introduction of several purified vaccines in the field of veterinary parasitology. Earlier, the conventional diagnostic methods was entirely based upon morphological taxonomy for diagnosis of parasites but nowadays improved molecular techniques help in phylogenetic study and open an another area of molecular taxonomy of parasites with high precision. Control measures based upon targeting endosymbionts in parasites like Dirofilaria immitis is also under exploration in veterinary parasitology. Metagenomics have added an inside story of parasites bionomics which have created havoc in human and animals population since centuries. Omics era is playing a key role in opening the new approaches on parasite biology. Various newer generations of safer vaccines like edible vaccines and subunit vaccines and diagnostic techniques based upon purified immunologically active epitopes have become commercially available against the parasites (helminths, protozoa and arthropod borne diseases). Nowadays, a transgenic and gene knock out studies using RNA interference and CRISPR are also helping in understanding the functions of genes and screening of target genes, which are not available before the advent of molecular tools. Molecular techniques had paramount impact on increasing the sensitivity of diagnostic tools, epidemiological studies and more importantly in controlling these diseases. This review is about the advancements in veterinary parasitology and their impact on the control of these pathogens.
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spelling pubmed-73870802020-07-29 Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance Kumar, Sachin Gupta, Snehil Mohmad, Aquil Fular, Ashutosh Parthasarathi, B. C. Chaubey, Ashok Kumar Int J Trop Insect Sci Mini-Review The recent advancement in genome sequencing facilities, proteomics, transcriptomics, and metabolomics of eukaryotes have opened door for employment of molecular diagnostic techniques for early detection of parasites and determining target molecules for formulating control strategies. It further leads to the introduction of several purified vaccines in the field of veterinary parasitology. Earlier, the conventional diagnostic methods was entirely based upon morphological taxonomy for diagnosis of parasites but nowadays improved molecular techniques help in phylogenetic study and open an another area of molecular taxonomy of parasites with high precision. Control measures based upon targeting endosymbionts in parasites like Dirofilaria immitis is also under exploration in veterinary parasitology. Metagenomics have added an inside story of parasites bionomics which have created havoc in human and animals population since centuries. Omics era is playing a key role in opening the new approaches on parasite biology. Various newer generations of safer vaccines like edible vaccines and subunit vaccines and diagnostic techniques based upon purified immunologically active epitopes have become commercially available against the parasites (helminths, protozoa and arthropod borne diseases). Nowadays, a transgenic and gene knock out studies using RNA interference and CRISPR are also helping in understanding the functions of genes and screening of target genes, which are not available before the advent of molecular tools. Molecular techniques had paramount impact on increasing the sensitivity of diagnostic tools, epidemiological studies and more importantly in controlling these diseases. This review is about the advancements in veterinary parasitology and their impact on the control of these pathogens. Springer International Publishing 2020-07-29 2021 /pmc/articles/PMC7387080/ /pubmed/32837530 http://dx.doi.org/10.1007/s42690-020-00213-9 Text en © African Association of Insect Scientists 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mini-Review
Kumar, Sachin
Gupta, Snehil
Mohmad, Aquil
Fular, Ashutosh
Parthasarathi, B. C.
Chaubey, Ashok Kumar
Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title_full Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title_fullStr Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title_full_unstemmed Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title_short Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
title_sort molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387080/
https://www.ncbi.nlm.nih.gov/pubmed/32837530
http://dx.doi.org/10.1007/s42690-020-00213-9
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