Cargando…
Effects of metabolic state on the regulation of melanocortin circuits
Dysfunction in neurophysiological systems that regulate food intake and metabolism are at least partly responsible for obesity and related comorbidities. An important component of this process is the hypothalamic melanocortin system, where an imbalance can result in severe obesity and deficits in gl...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387173/ https://www.ncbi.nlm.nih.gov/pubmed/32610101 http://dx.doi.org/10.1016/j.physbeh.2020.113039 |
_version_ | 1783564078977908736 |
---|---|
author | Lieu, Linh Chau, Dominic Afrin, Sadia Dong, Yanbin Alhadeff, Amber L. Betley, J. Nicholas Williams, Kevin W. |
author_facet | Lieu, Linh Chau, Dominic Afrin, Sadia Dong, Yanbin Alhadeff, Amber L. Betley, J. Nicholas Williams, Kevin W. |
author_sort | Lieu, Linh |
collection | PubMed |
description | Dysfunction in neurophysiological systems that regulate food intake and metabolism are at least partly responsible for obesity and related comorbidities. An important component of this process is the hypothalamic melanocortin system, where an imbalance can result in severe obesity and deficits in glucose metabolism. Exercise offers many health benefits related to cardiovascular improvements, hunger control, and blood glucose homeostasis. However, the molecular mechanism underlying the exercise-induced improvements to the melanocortin system remain undefined. Here, we review the role of the melanocortin system to sense hormonal, nutrient, and neuronal signals of energy status. This information is then relayed onto secondary neurons in order to regulate physiological parameters, which promote proper energy and glucose balance. We also provide an overview on the effects of physical exercise to induce biophysical changes in the melanocortin circuit which may regulate food intake, glucose metabolism and improve overall metabolic health. |
format | Online Article Text |
id | pubmed-7387173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-73871732020-10-01 Effects of metabolic state on the regulation of melanocortin circuits Lieu, Linh Chau, Dominic Afrin, Sadia Dong, Yanbin Alhadeff, Amber L. Betley, J. Nicholas Williams, Kevin W. Physiol Behav Article Dysfunction in neurophysiological systems that regulate food intake and metabolism are at least partly responsible for obesity and related comorbidities. An important component of this process is the hypothalamic melanocortin system, where an imbalance can result in severe obesity and deficits in glucose metabolism. Exercise offers many health benefits related to cardiovascular improvements, hunger control, and blood glucose homeostasis. However, the molecular mechanism underlying the exercise-induced improvements to the melanocortin system remain undefined. Here, we review the role of the melanocortin system to sense hormonal, nutrient, and neuronal signals of energy status. This information is then relayed onto secondary neurons in order to regulate physiological parameters, which promote proper energy and glucose balance. We also provide an overview on the effects of physical exercise to induce biophysical changes in the melanocortin circuit which may regulate food intake, glucose metabolism and improve overall metabolic health. 2020-06-28 2020-10-01 /pmc/articles/PMC7387173/ /pubmed/32610101 http://dx.doi.org/10.1016/j.physbeh.2020.113039 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Lieu, Linh Chau, Dominic Afrin, Sadia Dong, Yanbin Alhadeff, Amber L. Betley, J. Nicholas Williams, Kevin W. Effects of metabolic state on the regulation of melanocortin circuits |
title | Effects of metabolic state on the regulation of melanocortin circuits |
title_full | Effects of metabolic state on the regulation of melanocortin circuits |
title_fullStr | Effects of metabolic state on the regulation of melanocortin circuits |
title_full_unstemmed | Effects of metabolic state on the regulation of melanocortin circuits |
title_short | Effects of metabolic state on the regulation of melanocortin circuits |
title_sort | effects of metabolic state on the regulation of melanocortin circuits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387173/ https://www.ncbi.nlm.nih.gov/pubmed/32610101 http://dx.doi.org/10.1016/j.physbeh.2020.113039 |
work_keys_str_mv | AT lieulinh effectsofmetabolicstateontheregulationofmelanocortincircuits AT chaudominic effectsofmetabolicstateontheregulationofmelanocortincircuits AT afrinsadia effectsofmetabolicstateontheregulationofmelanocortincircuits AT dongyanbin effectsofmetabolicstateontheregulationofmelanocortincircuits AT alhadeffamberl effectsofmetabolicstateontheregulationofmelanocortincircuits AT betleyjnicholas effectsofmetabolicstateontheregulationofmelanocortincircuits AT williamskevinw effectsofmetabolicstateontheregulationofmelanocortincircuits |