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Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains...

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Detalles Bibliográficos
Autores principales:	Laurent, Anouchka P., Kotecha, Rishi S., Malinge, Sébastien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387246/ https://www.ncbi.nlm.nih.gov/pubmed/32433508 http://dx.doi.org/10.1038/s41375-020-0854-5

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