Cargando…
Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes
BACKGROUND: Care homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among st...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd on behalf of The British Infection Association.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387283/ https://www.ncbi.nlm.nih.gov/pubmed/32735893 http://dx.doi.org/10.1016/j.jinf.2020.07.027 |
_version_ | 1783564090403192832 |
---|---|
author | Ladhani, Shamez N Chow, J. Yimmy Janarthanan, Roshni Fok, Jonathan Crawley-Boevey, Emma Vusirikala, Amoolya Fernandez, Elena Perez, Marina Sanchez Tang, Suzanne Dun-Campbell, Kate Wynne-Evans, Edward Bell, Anita Patel, Bharat Amin-Chowdhury, Zahin Aiano, Felicity Paranthaman, Karthik Ma, Thomas Saavedra-Campos, Maria Myers, Richard Ellis, Joanna Lackenby, Angie Gopal, Robin Patel, Monika Chand, Meera Brown, Kevin Hopkins, Susan Consortium, CoG Shetty, Nandini Zambon, Maria Ramsay, Mary E |
author_facet | Ladhani, Shamez N Chow, J. Yimmy Janarthanan, Roshni Fok, Jonathan Crawley-Boevey, Emma Vusirikala, Amoolya Fernandez, Elena Perez, Marina Sanchez Tang, Suzanne Dun-Campbell, Kate Wynne-Evans, Edward Bell, Anita Patel, Bharat Amin-Chowdhury, Zahin Aiano, Felicity Paranthaman, Karthik Ma, Thomas Saavedra-Campos, Maria Myers, Richard Ellis, Joanna Lackenby, Angie Gopal, Robin Patel, Monika Chand, Meera Brown, Kevin Hopkins, Susan Consortium, CoG Shetty, Nandini Zambon, Maria Ramsay, Mary E |
author_sort | Ladhani, Shamez N |
collection | PubMed |
description | BACKGROUND: Care homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among staff in six care homes experiencing a COVID-19 outbreak during the peak of the pandemic in London, England. METHODS: Care home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. RESULTS: In total, 53 (21%) of 254 staff were SARS-CoV-2 positive but only 12/53 (23%) were symptomatic. Among staff working in a single care home, SARS-CoV-2 positivity was 15% (2/13), 16% (7/45) and 18% (30/169) in those reporting no, occasional and regular contact with residents. In contrast, staff working across different care homes (14/27, 52%) had a 3.0-fold (95% CI, 1.9–4.8; P<0.001) higher risk of SARS-CoV-2 positivity than staff working in single care homes (39/227, 17%). WGS identified SARS-CoV-2 clusters involving staff only, including some that included staff working across different care homes. CONCLUSIONS: SARS-CoV-2 positivity was significantly higher among staff working across different care homes than those who were working in the same care home. We found local clusters of SARS-CoV-2 infection between staff only, including those with minimal resident contact. Infection control should be extended for all contact, including those between staff, whilst on care home premises. |
format | Online Article Text |
id | pubmed-7387283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Ltd on behalf of The British Infection Association. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73872832020-07-29 Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes Ladhani, Shamez N Chow, J. Yimmy Janarthanan, Roshni Fok, Jonathan Crawley-Boevey, Emma Vusirikala, Amoolya Fernandez, Elena Perez, Marina Sanchez Tang, Suzanne Dun-Campbell, Kate Wynne-Evans, Edward Bell, Anita Patel, Bharat Amin-Chowdhury, Zahin Aiano, Felicity Paranthaman, Karthik Ma, Thomas Saavedra-Campos, Maria Myers, Richard Ellis, Joanna Lackenby, Angie Gopal, Robin Patel, Monika Chand, Meera Brown, Kevin Hopkins, Susan Consortium, CoG Shetty, Nandini Zambon, Maria Ramsay, Mary E J Infect Article BACKGROUND: Care homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among staff in six care homes experiencing a COVID-19 outbreak during the peak of the pandemic in London, England. METHODS: Care home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. RESULTS: In total, 53 (21%) of 254 staff were SARS-CoV-2 positive but only 12/53 (23%) were symptomatic. Among staff working in a single care home, SARS-CoV-2 positivity was 15% (2/13), 16% (7/45) and 18% (30/169) in those reporting no, occasional and regular contact with residents. In contrast, staff working across different care homes (14/27, 52%) had a 3.0-fold (95% CI, 1.9–4.8; P<0.001) higher risk of SARS-CoV-2 positivity than staff working in single care homes (39/227, 17%). WGS identified SARS-CoV-2 clusters involving staff only, including some that included staff working across different care homes. CONCLUSIONS: SARS-CoV-2 positivity was significantly higher among staff working across different care homes than those who were working in the same care home. We found local clusters of SARS-CoV-2 infection between staff only, including those with minimal resident contact. Infection control should be extended for all contact, including those between staff, whilst on care home premises. Published by Elsevier Ltd on behalf of The British Infection Association. 2020-10 2020-07-29 /pmc/articles/PMC7387283/ /pubmed/32735893 http://dx.doi.org/10.1016/j.jinf.2020.07.027 Text en © 2020 Published by Elsevier Ltd on behalf of The British Infection Association. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ladhani, Shamez N Chow, J. Yimmy Janarthanan, Roshni Fok, Jonathan Crawley-Boevey, Emma Vusirikala, Amoolya Fernandez, Elena Perez, Marina Sanchez Tang, Suzanne Dun-Campbell, Kate Wynne-Evans, Edward Bell, Anita Patel, Bharat Amin-Chowdhury, Zahin Aiano, Felicity Paranthaman, Karthik Ma, Thomas Saavedra-Campos, Maria Myers, Richard Ellis, Joanna Lackenby, Angie Gopal, Robin Patel, Monika Chand, Meera Brown, Kevin Hopkins, Susan Consortium, CoG Shetty, Nandini Zambon, Maria Ramsay, Mary E Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title | Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title_full | Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title_fullStr | Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title_full_unstemmed | Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title_short | Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes |
title_sort | increased risk of sars-cov-2 infection in staff working across different care homes: enhanced covid-19 outbreak investigations in london care homes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387283/ https://www.ncbi.nlm.nih.gov/pubmed/32735893 http://dx.doi.org/10.1016/j.jinf.2020.07.027 |
work_keys_str_mv | AT ladhanishamezn increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT chowjyimmy increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT janarthananroshni increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT fokjonathan increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT crawleyboeveyemma increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT vusirikalaamoolya increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT fernandezelena increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT perezmarinasanchez increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT tangsuzanne increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT duncampbellkate increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT wynneevansedward increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT bellanita increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT patelbharat increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT aminchowdhuryzahin increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT aianofelicity increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT paranthamankarthik increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT mathomas increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT saavedracamposmaria increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT myersrichard increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT ellisjoanna increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT lackenbyangie increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT gopalrobin increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT patelmonika increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT chandmeera increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT brownkevin increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT hopkinssusan increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT consortiumcog increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT shettynandini increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT zambonmaria increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT ramsaymarye increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes AT increasedriskofsarscov2infectioninstaffworkingacrossdifferentcarehomesenhancedcovid19outbreakinvestigationsinlondoncarehomes |