Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia

Therapy resistance in leukemia may be due to cancer cell-intrinsic and/or -extrinsic mechanisms. Mutations within BCR-ABL1, the oncogene giving rise to chronic myeloid leukemia (CML), lead to resistance to tyrosine kinase inhibitors (TKI), and some are associated with clinically more aggressive dise...

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Detalles Bibliográficos
Autores principales: Kumar, Rahul, Pereira, Raquel S., Zanetti, Costanza, Minciacchi, Valentina R., Merten, Maximilian, Meister, Melanie, Niemann, Julian, Dietz, Marina S., Rüssel, Nina, Schnütgen, Frank, Tamai, Minori, Akahane, Koshi, Inukai, Takeshi, Oellerich, Thomas, Kvasnicka, Hans Michael, Pfeifer, Heike, Nicolini, Franck E., Heilemann, Mike, Van Etten, Richard A., Krause, Daniela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387317/
https://www.ncbi.nlm.nih.gov/pubmed/32439895
http://dx.doi.org/10.1038/s41375-020-0866-1

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