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Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium
Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs are well known by their feature of self-renewal and their differentiation potential. NESTIN is a cytoskeletal protein expressed in MSC that functions directly in cell proliferation and differentiation. H...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387401/ https://www.ncbi.nlm.nih.gov/pubmed/32725504 http://dx.doi.org/10.1186/s13568-020-01067-7 |
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author | Liu, Yuncheng Xiao, Feidi Hu, Xiang Tang, Zan Fu, Zeqin Liang, Xiao Zeng, Guifang Zeng, Weijie Liao, Yan Ren, Yuan Liu, Zhiyu Peng, Hao Mei, Qiuhong Liu, Muyun |
author_facet | Liu, Yuncheng Xiao, Feidi Hu, Xiang Tang, Zan Fu, Zeqin Liang, Xiao Zeng, Guifang Zeng, Weijie Liao, Yan Ren, Yuan Liu, Zhiyu Peng, Hao Mei, Qiuhong Liu, Muyun |
author_sort | Liu, Yuncheng |
collection | PubMed |
description | Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs are well known by their feature of self-renewal and their differentiation potential. NESTIN is a cytoskeletal protein expressed in MSC that functions directly in cell proliferation and differentiation. Here, we demonstrated that adding UltraGRO, a medium supplement, could maintain and partially recover the expression of NESTIN in human umbilical cord derived MSCs (UC-MSCs). Furthermore, the UC-MSCs cultured with UltraGRO showed a better immunomodulation ability in a colitis mouse model compared with those cultured in other types of media. This indicates that the use of novel culture medium benefits the maintenance of NESTIN expression and NESTIN may be one of the vital factors that regulates the performance of MSCs. |
format | Online Article Text |
id | pubmed-7387401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73874012020-08-12 Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium Liu, Yuncheng Xiao, Feidi Hu, Xiang Tang, Zan Fu, Zeqin Liang, Xiao Zeng, Guifang Zeng, Weijie Liao, Yan Ren, Yuan Liu, Zhiyu Peng, Hao Mei, Qiuhong Liu, Muyun AMB Express Original Article Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs are well known by their feature of self-renewal and their differentiation potential. NESTIN is a cytoskeletal protein expressed in MSC that functions directly in cell proliferation and differentiation. Here, we demonstrated that adding UltraGRO, a medium supplement, could maintain and partially recover the expression of NESTIN in human umbilical cord derived MSCs (UC-MSCs). Furthermore, the UC-MSCs cultured with UltraGRO showed a better immunomodulation ability in a colitis mouse model compared with those cultured in other types of media. This indicates that the use of novel culture medium benefits the maintenance of NESTIN expression and NESTIN may be one of the vital factors that regulates the performance of MSCs. Springer Berlin Heidelberg 2020-07-28 /pmc/articles/PMC7387401/ /pubmed/32725504 http://dx.doi.org/10.1186/s13568-020-01067-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Liu, Yuncheng Xiao, Feidi Hu, Xiang Tang, Zan Fu, Zeqin Liang, Xiao Zeng, Guifang Zeng, Weijie Liao, Yan Ren, Yuan Liu, Zhiyu Peng, Hao Mei, Qiuhong Liu, Muyun Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title | Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title_full | Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title_fullStr | Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title_full_unstemmed | Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title_short | Recovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture medium |
title_sort | recovery and maintenance of nestin expression in umbilical cord-msc using a novel culture medium |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387401/ https://www.ncbi.nlm.nih.gov/pubmed/32725504 http://dx.doi.org/10.1186/s13568-020-01067-7 |
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