Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation. For instance, deficiency in complement regulators CD55 and CD59, leads to paroxysmal nocturnal hemoglobinuria (PNH), whereas Factor H muta...

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Detalles Bibliográficos
Autores principales: Chen, Jin Y., Galwankar, Neeti S., Emch, Heather N., Menon, Smrithi S., Cortes, Claudio, Thurman, Joshua M., Merrill, Samuel A., Brodsky, Robert A., Ferreira, Viviana P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387411/
https://www.ncbi.nlm.nih.gov/pubmed/32793201
http://dx.doi.org/10.3389/fimmu.2020.01460

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