Cargando…

Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation

Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate th...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Ki-Woong, Kim, Chi Kyung, Yu, Sungwook, Chung, Jong-Won, Bang, Oh Young, Kim, Gyeong-Moon, Jung, Jin-Man, Song, Tae-Jin, Kim, Yong-Jae, Kim, Bum Joon, Heo, Sung Hyuk, Park, Kwang-Yeol, Kim, Jeong-Min, Park, Jong-Ho, Choi, Jay Chol, Park, Man-Seok, Kim, Joon-Tae, Choi, Kang-Ho, Hwang, Yang Ha, Seo, Woo-Keun, Oh, Kyungmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387448/
https://www.ncbi.nlm.nih.gov/pubmed/32724110
http://dx.doi.org/10.1038/s41598-020-69303-5
_version_ 1783564121686409216
author Nam, Ki-Woong
Kim, Chi Kyung
Yu, Sungwook
Chung, Jong-Won
Bang, Oh Young
Kim, Gyeong-Moon
Jung, Jin-Man
Song, Tae-Jin
Kim, Yong-Jae
Kim, Bum Joon
Heo, Sung Hyuk
Park, Kwang-Yeol
Kim, Jeong-Min
Park, Jong-Ho
Choi, Jay Chol
Park, Man-Seok
Kim, Joon-Tae
Choi, Kang-Ho
Hwang, Yang Ha
Seo, Woo-Keun
Oh, Kyungmi
author_facet Nam, Ki-Woong
Kim, Chi Kyung
Yu, Sungwook
Chung, Jong-Won
Bang, Oh Young
Kim, Gyeong-Moon
Jung, Jin-Man
Song, Tae-Jin
Kim, Yong-Jae
Kim, Bum Joon
Heo, Sung Hyuk
Park, Kwang-Yeol
Kim, Jeong-Min
Park, Jong-Ho
Choi, Jay Chol
Park, Man-Seok
Kim, Joon-Tae
Choi, Kang-Ho
Hwang, Yang Ha
Seo, Woo-Keun
Oh, Kyungmi
author_sort Nam, Ki-Woong
collection PubMed
description Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00–1.34; P = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00–1.06; P = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23–0.54; P < 0.001) and new oral anticoagulants (aOR = 0.41, 95% CI 0.19–0.89; P = 0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke.
format Online
Article
Text
id pubmed-7387448
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73874482020-07-29 Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation Nam, Ki-Woong Kim, Chi Kyung Yu, Sungwook Chung, Jong-Won Bang, Oh Young Kim, Gyeong-Moon Jung, Jin-Man Song, Tae-Jin Kim, Yong-Jae Kim, Bum Joon Heo, Sung Hyuk Park, Kwang-Yeol Kim, Jeong-Min Park, Jong-Ho Choi, Jay Chol Park, Man-Seok Kim, Joon-Tae Choi, Kang-Ho Hwang, Yang Ha Seo, Woo-Keun Oh, Kyungmi Sci Rep Article Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00–1.34; P = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00–1.06; P = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23–0.54; P < 0.001) and new oral anticoagulants (aOR = 0.41, 95% CI 0.19–0.89; P = 0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke. Nature Publishing Group UK 2020-07-28 /pmc/articles/PMC7387448/ /pubmed/32724110 http://dx.doi.org/10.1038/s41598-020-69303-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nam, Ki-Woong
Kim, Chi Kyung
Yu, Sungwook
Chung, Jong-Won
Bang, Oh Young
Kim, Gyeong-Moon
Jung, Jin-Man
Song, Tae-Jin
Kim, Yong-Jae
Kim, Bum Joon
Heo, Sung Hyuk
Park, Kwang-Yeol
Kim, Jeong-Min
Park, Jong-Ho
Choi, Jay Chol
Park, Man-Seok
Kim, Joon-Tae
Choi, Kang-Ho
Hwang, Yang Ha
Seo, Woo-Keun
Oh, Kyungmi
Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title_full Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title_fullStr Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title_full_unstemmed Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title_short Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
title_sort elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387448/
https://www.ncbi.nlm.nih.gov/pubmed/32724110
http://dx.doi.org/10.1038/s41598-020-69303-5
work_keys_str_mv AT namkiwoong elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimchikyung elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT yusungwook elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT chungjongwon elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT bangohyoung elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimgyeongmoon elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT jungjinman elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT songtaejin elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimyongjae elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimbumjoon elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT heosunghyuk elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT parkkwangyeol elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimjeongmin elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT parkjongho elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT choijaychol elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT parkmanseok elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT kimjoontae elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT choikangho elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT hwangyangha elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT seowookeun elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation
AT ohkyungmi elevatedtroponinlevelsareassociatedwithearlyneurologicalworseninginischemicstrokewithatrialfibrillation