The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investi...

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Autores principales: Takeuchi, Hikarua, Taki, Yasuyuki, Nouchi, Rui, Yokoyama, Ryoichi, Nakagawa, Seishu, Iizuka, Kunio, Sakaki, Kohei, Araki, Tsuyoshi, Nozawa, Takayuki, Ikeda, Shigeyuki, Yokota, Susumu, Hanawa, Sugiko, Magistro, Daniele, Kotozaki, Yuka, Sasaki, Yukako, dos S. Kawata, Kelssy H., Kawashima, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387490/
https://www.ncbi.nlm.nih.gov/pubmed/32724120
http://dx.doi.org/10.1038/s41598-020-69438-5
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author Takeuchi, Hikarua
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Iizuka, Kunio
Sakaki, Kohei
Araki, Tsuyoshi
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Hanawa, Sugiko
Magistro, Daniele
Kotozaki, Yuka
Sasaki, Yukako
dos S. Kawata, Kelssy H.
Kawashima, Ryuta
author_facet Takeuchi, Hikarua
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Iizuka, Kunio
Sakaki, Kohei
Araki, Tsuyoshi
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Hanawa, Sugiko
Magistro, Daniele
Kotozaki, Yuka
Sasaki, Yukako
dos S. Kawata, Kelssy H.
Kawashima, Ryuta
author_sort Takeuchi, Hikarua
collection PubMed
description Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.
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spelling pubmed-73874902020-07-29 The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity Takeuchi, Hikarua Taki, Yasuyuki Nouchi, Rui Yokoyama, Ryoichi Nakagawa, Seishu Iizuka, Kunio Sakaki, Kohei Araki, Tsuyoshi Nozawa, Takayuki Ikeda, Shigeyuki Yokota, Susumu Hanawa, Sugiko Magistro, Daniele Kotozaki, Yuka Sasaki, Yukako dos S. Kawata, Kelssy H. Kawashima, Ryuta Sci Rep Article Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity. Nature Publishing Group UK 2020-07-28 /pmc/articles/PMC7387490/ /pubmed/32724120 http://dx.doi.org/10.1038/s41598-020-69438-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Takeuchi, Hikarua
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Nakagawa, Seishu
Iizuka, Kunio
Sakaki, Kohei
Araki, Tsuyoshi
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Hanawa, Sugiko
Magistro, Daniele
Kotozaki, Yuka
Sasaki, Yukako
dos S. Kawata, Kelssy H.
Kawashima, Ryuta
The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_full The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_fullStr The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_full_unstemmed The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_short The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_sort associations of bmi with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387490/
https://www.ncbi.nlm.nih.gov/pubmed/32724120
http://dx.doi.org/10.1038/s41598-020-69438-5
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