The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases

Storage and directed transfer of information is the key requirement for the development of life. Yet any information stored on our genes is useless without its correct interpretation. The genetic code defines the rule set to decode this information. Aminoacyl-tRNA synthetases are at the heart of thi...

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Autores principales: Kaiser, Florian, Krautwurst, Sarah, Salentin, Sebastian, Haupt, V. Joachim, Leberecht, Christoph, Bittrich, Sebastian, Labudde, Dirk, Schroeder, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387524/
https://www.ncbi.nlm.nih.gov/pubmed/32724042
http://dx.doi.org/10.1038/s41598-020-69100-0
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author Kaiser, Florian
Krautwurst, Sarah
Salentin, Sebastian
Haupt, V. Joachim
Leberecht, Christoph
Bittrich, Sebastian
Labudde, Dirk
Schroeder, Michael
author_facet Kaiser, Florian
Krautwurst, Sarah
Salentin, Sebastian
Haupt, V. Joachim
Leberecht, Christoph
Bittrich, Sebastian
Labudde, Dirk
Schroeder, Michael
author_sort Kaiser, Florian
collection PubMed
description Storage and directed transfer of information is the key requirement for the development of life. Yet any information stored on our genes is useless without its correct interpretation. The genetic code defines the rule set to decode this information. Aminoacyl-tRNA synthetases are at the heart of this process. We extensively characterize how these enzymes distinguish all natural amino acids based on the computational analysis of crystallographic structure data. The results of this meta-analysis show that the correct read-out of genetic information is a delicate interplay between the composition of the binding site, non-covalent interactions, error correction mechanisms, and steric effects.
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spelling pubmed-73875242020-07-29 The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases Kaiser, Florian Krautwurst, Sarah Salentin, Sebastian Haupt, V. Joachim Leberecht, Christoph Bittrich, Sebastian Labudde, Dirk Schroeder, Michael Sci Rep Article Storage and directed transfer of information is the key requirement for the development of life. Yet any information stored on our genes is useless without its correct interpretation. The genetic code defines the rule set to decode this information. Aminoacyl-tRNA synthetases are at the heart of this process. We extensively characterize how these enzymes distinguish all natural amino acids based on the computational analysis of crystallographic structure data. The results of this meta-analysis show that the correct read-out of genetic information is a delicate interplay between the composition of the binding site, non-covalent interactions, error correction mechanisms, and steric effects. Nature Publishing Group UK 2020-07-28 /pmc/articles/PMC7387524/ /pubmed/32724042 http://dx.doi.org/10.1038/s41598-020-69100-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kaiser, Florian
Krautwurst, Sarah
Salentin, Sebastian
Haupt, V. Joachim
Leberecht, Christoph
Bittrich, Sebastian
Labudde, Dirk
Schroeder, Michael
The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title_full The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title_fullStr The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title_full_unstemmed The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title_short The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
title_sort structural basis of the genetic code: amino acid recognition by aminoacyl-trna synthetases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387524/
https://www.ncbi.nlm.nih.gov/pubmed/32724042
http://dx.doi.org/10.1038/s41598-020-69100-0
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