Cargando…

Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report

Hypoglycemia is a serious event in older patients with diabetes mellitus because it increases the risk of various conditions including cardiovascular disease, and dementia, as well as the risk of falls in these individuals. Quetiapine is a widely used antipsychotic drug with diverse indications, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Suk Ju, Lee, Sang Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Geriatrics Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387607/
https://www.ncbi.nlm.nih.gov/pubmed/32743284
http://dx.doi.org/10.4235/agmr.18.0050
_version_ 1783564158507155456
author Cho, Suk Ju
Lee, Sang Ah
author_facet Cho, Suk Ju
Lee, Sang Ah
author_sort Cho, Suk Ju
collection PubMed
description Hypoglycemia is a serious event in older patients with diabetes mellitus because it increases the risk of various conditions including cardiovascular disease, and dementia, as well as the risk of falls in these individuals. Quetiapine is a widely used antipsychotic drug with diverse indications, and it may be prescribed to older patients. We report on our treatment of an older individual without diabetes mellitus who manifested severe hypoglycemia induced by quetiapine. The hypoglycemia was accompanied by endogenous hyperinsulinemia but was not related to the presence of a pancreatic tumor or antibodies, and adrenal function was normal. The hypoglycemia was so severe that only massive 20% dextrose infusion could maintain normoglycemia. After the patient stopped taking quetiapine, his blood glucose concentration started to increase slowly toward normoglycemia. We finally diagnosed this case as quetiapine-related severe hypoglycemia in a patient without diabetes mellitus, and report our findings here.
format Online
Article
Text
id pubmed-7387607
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Korean Geriatrics Society
record_format MEDLINE/PubMed
spelling pubmed-73876072020-07-30 Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report Cho, Suk Ju Lee, Sang Ah Ann Geriatr Med Res Case Report Hypoglycemia is a serious event in older patients with diabetes mellitus because it increases the risk of various conditions including cardiovascular disease, and dementia, as well as the risk of falls in these individuals. Quetiapine is a widely used antipsychotic drug with diverse indications, and it may be prescribed to older patients. We report on our treatment of an older individual without diabetes mellitus who manifested severe hypoglycemia induced by quetiapine. The hypoglycemia was accompanied by endogenous hyperinsulinemia but was not related to the presence of a pancreatic tumor or antibodies, and adrenal function was normal. The hypoglycemia was so severe that only massive 20% dextrose infusion could maintain normoglycemia. After the patient stopped taking quetiapine, his blood glucose concentration started to increase slowly toward normoglycemia. We finally diagnosed this case as quetiapine-related severe hypoglycemia in a patient without diabetes mellitus, and report our findings here. Korean Geriatrics Society 2019-03 2019-03-31 /pmc/articles/PMC7387607/ /pubmed/32743284 http://dx.doi.org/10.4235/agmr.18.0050 Text en Copyright © 2019 by The Korean Geriatric Society This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cho, Suk Ju
Lee, Sang Ah
Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title_full Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title_fullStr Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title_full_unstemmed Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title_short Quetiapine-Induced Severe Hypoglycemia in Patient Without Diabetes Mellitus: A Case Report
title_sort quetiapine-induced severe hypoglycemia in patient without diabetes mellitus: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387607/
https://www.ncbi.nlm.nih.gov/pubmed/32743284
http://dx.doi.org/10.4235/agmr.18.0050
work_keys_str_mv AT chosukju quetiapineinducedseverehypoglycemiainpatientwithoutdiabetesmellitusacasereport
AT leesangah quetiapineinducedseverehypoglycemiainpatientwithoutdiabetesmellitusacasereport