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Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma

Gender differences in esophageal cancer patients indicate that estradiol may have antitumor effects on esophageal cancer. The initiation of endoplasmic reticulum stress (ERS) can induce apoptosis in esophageal cancer cells. However, it is still unknown whether estradiol inhibits the development of e...

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Autores principales: Wang, Chen, Wang, Peng, Liu, Jun-Chao, Zhao, Zhen-Ao, Guo, Rui, Li, Ying, Liu, Ya-Sen, Li, Shu-Guang, Zhao, Zi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387645/
https://www.ncbi.nlm.nih.gov/pubmed/32793111
http://dx.doi.org/10.3389/fendo.2020.00410
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author Wang, Chen
Wang, Peng
Liu, Jun-Chao
Zhao, Zhen-Ao
Guo, Rui
Li, Ying
Liu, Ya-Sen
Li, Shu-Guang
Zhao, Zi-Gang
author_facet Wang, Chen
Wang, Peng
Liu, Jun-Chao
Zhao, Zhen-Ao
Guo, Rui
Li, Ying
Liu, Ya-Sen
Li, Shu-Guang
Zhao, Zi-Gang
author_sort Wang, Chen
collection PubMed
description Gender differences in esophageal cancer patients indicate that estradiol may have antitumor effects on esophageal cancer. The initiation of endoplasmic reticulum stress (ERS) can induce apoptosis in esophageal cancer cells. However, it is still unknown whether estradiol inhibits the development of esophageal cancer by activating ERS pathway. In this study, the gender difference in the development of esophageal cancer was observed by analyzing clinical data and the experimental tumor xenografts in mice. Meanwhile, we investigated the mechanism of ERS in estradiol-mediated inhibition of esophageal cancer using esophageal squamous cell carcinoma cell line EC109. The proportion of male patients with esophageal cancer was significantly higher than female patients. Meanwhile, male patients were prone to have adventitial invasion. The weight of transplanted tumors in female mice was significantly smaller than that in male mice. In vitro experiments showed estradiol inhibits the viability and migration of EC109 cells by increasing the expression of ERS-related proteins, whereas ERS inhibitor 4-PBA abolished the effects of estradiol. In conclusion, our data demonstrate that sex difference exists in the occurrence of esophageal cancer. Estradiol can inhibit the viability and migration of esophageal cancer cells through the activation of ERS, providing a novel insight for esophageal cancer development, treatment, and prevention.
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spelling pubmed-73876452020-08-12 Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma Wang, Chen Wang, Peng Liu, Jun-Chao Zhao, Zhen-Ao Guo, Rui Li, Ying Liu, Ya-Sen Li, Shu-Guang Zhao, Zi-Gang Front Endocrinol (Lausanne) Endocrinology Gender differences in esophageal cancer patients indicate that estradiol may have antitumor effects on esophageal cancer. The initiation of endoplasmic reticulum stress (ERS) can induce apoptosis in esophageal cancer cells. However, it is still unknown whether estradiol inhibits the development of esophageal cancer by activating ERS pathway. In this study, the gender difference in the development of esophageal cancer was observed by analyzing clinical data and the experimental tumor xenografts in mice. Meanwhile, we investigated the mechanism of ERS in estradiol-mediated inhibition of esophageal cancer using esophageal squamous cell carcinoma cell line EC109. The proportion of male patients with esophageal cancer was significantly higher than female patients. Meanwhile, male patients were prone to have adventitial invasion. The weight of transplanted tumors in female mice was significantly smaller than that in male mice. In vitro experiments showed estradiol inhibits the viability and migration of EC109 cells by increasing the expression of ERS-related proteins, whereas ERS inhibitor 4-PBA abolished the effects of estradiol. In conclusion, our data demonstrate that sex difference exists in the occurrence of esophageal cancer. Estradiol can inhibit the viability and migration of esophageal cancer cells through the activation of ERS, providing a novel insight for esophageal cancer development, treatment, and prevention. Frontiers Media S.A. 2020-07-22 /pmc/articles/PMC7387645/ /pubmed/32793111 http://dx.doi.org/10.3389/fendo.2020.00410 Text en Copyright © 2020 Wang, Wang, Liu, Zhao, Guo, Li, Liu, Li and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Chen
Wang, Peng
Liu, Jun-Chao
Zhao, Zhen-Ao
Guo, Rui
Li, Ying
Liu, Ya-Sen
Li, Shu-Guang
Zhao, Zi-Gang
Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title_full Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title_fullStr Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title_full_unstemmed Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title_short Interaction of Estradiol and Endoplasmic Reticulum Stress in the Development of Esophageal Carcinoma
title_sort interaction of estradiol and endoplasmic reticulum stress in the development of esophageal carcinoma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387645/
https://www.ncbi.nlm.nih.gov/pubmed/32793111
http://dx.doi.org/10.3389/fendo.2020.00410
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