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Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting

Interferon (IFN)-inducible guanylate binding proteins (GBPs) play important roles in host defense against many intracellular pathogens that reside within pathogen-containing vacuoles (PVs). For instance, members of the GBP family translocate to PVs occupied by the protozoan pathogen Toxoplasma and f...

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Detalles Bibliográficos
Autores principales: Haldar, Arun Kumar, Nigam, Utsav, Yamamoto, Masahiro, Coers, Jörn, Goyal, Neena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387799/
https://www.ncbi.nlm.nih.gov/pubmed/32723921
http://dx.doi.org/10.1128/mBio.01464-20